Association studies of neurotransmitter gene polymorphisms in alcoholic Caucasians
| Autor: | E. W. Loh, A. E. G. Tannenberg, Peter R. Dodd, Clive Harper, David J. Innes, S. M. Williams, P. F. Foley |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
TaqI
Genetic Linkage Population Pharmacology General Biochemistry Genetics and Molecular Biology White People chemistry.chemical_compound History and Philosophy of Science Gene Frequency Dopamine Dopamine receptor D2 medicine Confidence Intervals Odds Ratio Humans Neurotransmitter education Serotonin transporter Dopamine transporter education.field_of_study Neurotransmitter Agents Chi-Square Distribution Polymorphism Genetic biology General Neuroscience Glutamate receptor Brain Alcoholism chemistry biology.protein medicine.drug |
| Zdroj: | Annals of the New York Academy of Sciences. 1025 |
| ISSN: | 0077-8923 |
| Popis: | Ethanol enhances mesolimbic/cortical dopamine activity in reward and reinforcement circuits. We investigated the hypothesis that risk for alcoholism may be mediated by genes for neurotransmitters associated with the dopamine reward system as well as genes for enzymes involved in ethanol metabolism. DNA was extracted from brain tissue collected at autopsy from pathologically characterized alcoholics and controls. PCR-based assays showed that alcoholism was associated with polymorphisms of the dopamine D2 receptor (DRD2) TaqI B (P = .029) and the GABAA-beta2 subunit C1412T (P = .012) genes, but not with the glutamate receptor subunit gene NMDAR2B (366C/G), the serotonin transporter gene (5HTTL-PR), the dopamine transporter gene DAT1(SLC6A3), the dopamine D2 receptor gene DRD2 TaqI A, or the GABAA alpha1(A15G), alpha6(T1519C), and gamma2(G3145A) subunit genes. The glial glutamate transporter gene EAAT2 polymorphism G603A was associated with alcoholic cirrhosis (P = .048). The genotype for the most active alcohol dehydrogenase enzyme ADH1C was associated with a lower risk of alcoholism (P = .026) and was less prevalent in alcoholics with DRD2TaqIA2/A2 (P = .047), GABAA-beta2 1412C/C (P = .01), or EAAT2 603G/A (P = .022) genotypes. Combined DRD2TaqI A or B with GABAA-beta2 or EAAT2 G603A genotypes may have a concerted influence in the predisposition to alcoholism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text