CST, an Herbal Formula, Exerts Anti-Obesity Effects through Brain-Gut-Adipose Tissue Axis Modulation in High-Fat Diet Fed Mice
| Autor: | Jing-Hua Wang, Hojun Kim, AbuZar Ansari, Seong-Gyu Ko, Yun-Kyung Song, Mukesh Kumar Yadav, Shambhunath Bose |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine obesity Pharmaceutical Science Adipose tissue Analytical Chemistry Mice 0302 clinical medicine Liver Function Tests Drug Discovery Insulin Adiposity biology digestive oral and skin physiology Brain Organ Size Neuropeptide Y receptor Lipids chowiseungcheng-tang Adipose Tissue Chemistry (miscellaneous) Hypothalamus 030220 oncology & carcinogenesis Molecular Medicine medicine.drug medicine.medical_specialty Adipokine Neuropeptide Diet High-Fat Article lcsh:QD241-441 03 medical and health sciences lcsh:Organic chemistry Adipokines Proopiomelanocortin Internal medicine medicine Animals Physical and Theoretical Chemistry neuropeptide adipokine gut microbiota Adiponectin Plant Extracts Body Weight Neuropeptides Organic Chemistry brain-gut-adipose tissue axis Gastrointestinal Microbiome Gastrointestinal Tract Disease Models Animal Orlistat 030104 developmental biology Endocrinology Gene Expression Regulation herb biology.protein Anti-Obesity Agents Energy Metabolism human activities Biomarkers |
| Zdroj: | Molecules; Volume 21; Issue 11; Pages: 1522 Molecules Molecules, Vol 21, Iss 11, p 1522 (2016) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules21111522 |
| Popis: | The brain, gut, and adipose tissue interact to control metabolic pathways, and impairment in the brain-gut-adipose axis can lead to metabolic disorders, including obesity. Chowiseungcheng-tang (CST), a herbal formulation, is frequently used to treat metabolic disorders. Here, we investigated the anti-obesity effect of CST and its link with brain-gut-adipose axis using C57BL/6J mice as a model. The animals were provided with a normal research diet (NRD) or high-fat diet (HFD) in absence or presence of CST or orlistat (ORL) for 12 weeks. CST had a significant anti-obesity effect on a number of vital metabolic and obesity-related parameters in HFD-fed mice. CST significantly decreased the expression levels of genes encoding obesity-promoting neuropeptides (agouti-related peptide, neuropeptide Y), and increased the mRNA levels of obesity-suppressing neuropeptides (proopiomelanocortin, cocaine-and amphetamine-regulated transcript) in the hypothalamus. CST also effectively decreased the expression level of gene encoding obesity-promoting adipokine (retinol-binding protein-4) and increased the mRNA level of obesity-suppressing adipokine (adiponectin) in visceral adipose tissue (VAT). Additionally, CST altered the gut microbial composition in HFD groups, a phenomenon strongly associated with key metabolic parameters, neuropeptides, and adipokines. Our findings reveal that the anti-obesity impact of CST is mediated through modulation of metabolism-related neuropeptides, adipokines, and gut microbial composition. |
| Databáze: | OpenAIRE |
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