Effect of Hyperbaric Oxygen on Tissue Damage and Expression of Adhesion Molecules and C3 in a Rat Model of Renal Ischemia-Reperfusion Injury After Kidney Transplantation
| Autor: | Zifeng Fu, Hao Li, Yang Du, Anjian Chen, Ding-Su Bao, Jiang Du, Guobiao Liang, Xin Wang, Faliang Zhao, Tiancai Liang, Yuanliang Wang, Zhi-Hui Xie |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Ischemia Reperfusion Injury Urology Complement Adhesion (medicine) Renal function Vascular Cell Adhesion Molecule-1 Kidney Adhesion Molecule Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Hyperbaric oxygen medicine Animals Hyperbaric Oxygen Kidney transplantation Transplantation Creatinine Hyperbaric Oxygenation Original Paper Cell adhesion molecule business.industry General Medicine Complement C3 medicine.disease Intercellular Adhesion Molecule-1 Kidney Transplantation Complement system Rats 030104 developmental biology chemistry 030220 oncology & carcinogenesis Reperfusion Injury Models Animal Immunohistochemistry Rat business |
| Zdroj: | Annals of Transplantation |
| ISSN: | 2329-0358 |
| Popis: | BACKGROUND The aim of this study was to investigate the protective effect and mechanism of hyperbaric oxygen (HBO) in a rat model of renal ischemia-reperfusion injury following kidney transplantation. MATERIAL AND METHODS Sprague Dawley rats were randomly divided into 3 groups (n=18): sham group, kidney transplantation group, and HBO treatment group. Six rats in each group were sacrificed at 1, 3, and 5 hours after reperfusion, and serum and renal tissue were then collected. The serum creatinine levels and histopathological changes of the renal tissue were detected. ICAM-1, VCAM-1, and C3 expression levels were also detected by immunohistochemical staining or real-time polymerase chain reaction. RESULTS Renal function was damaged in the kidney transplantation group and the HBO treatment group compared with sham group (P |
| Databáze: | OpenAIRE |
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