LRIG1-Mediated Inhibition of EGF Receptor Signaling Regulates Neural Precursor Cell Proliferation in the Neocortex
| Autor: | Danielle Jeong, David L. Kaplan, Freda D. Miller, Archana Gengatharan, Kyshona Edwards, Scott A. Yuzwa, Armen Saghatelyan, Daniela Lozano Casasbuenas |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cell type Neural precursor cell proliferation Neurogenesis Embryonic Development Neocortex Nerve Tissue Proteins General Biochemistry Genetics and Molecular Biology Receptor tyrosine kinase 03 medical and health sciences Mice 0302 clinical medicine Neural Stem Cells medicine Animals Epidermal growth factor receptor Cell Self Renewal reproductive and urinary physiology Cell Proliferation Mice Knockout Membrane Glycoproteins biology Embryogenesis Embryo Mammalian Neural stem cell nervous system diseases Cell biology ErbB Receptors 030104 developmental biology medicine.anatomical_structure nervous system Animals Newborn biology.protein biological phenomena cell phenomena and immunity Stem cell 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Cell reports. 33(2) |
| ISSN: | 2211-1247 |
| Popis: | Here, we ask how neural stem cells (NSCs) transition in the developing neocortex from a rapidly to a slowly proliferating state, a process required to maintain lifelong stem cell pools. We identify LRIG1, known to regulate receptor tyrosine kinase signaling in other cell types, as a negative regulator of cortical NSC proliferation. LRIG1 is expressed in murine cortical NSCs as they start to proliferate more slowly during embryogenesis and then peaks postnatally when they transition to give rise to a portion of adult NSCs. Constitutive or acute loss of Lrig1 in NSCs over this developmental time frame causes stem cell expansion due to increased proliferation. LRIG1 controls NSC proliferation by associating with and negatively regulating the epidermal growth factor receptor (EGFR). These data support a model in which LRIG1 dampens the stem cell response to EGFR ligands within the cortical environment to slow their proliferation as they transition to postnatal adult NSCs. |
| Databáze: | OpenAIRE |
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