Inhibition of angiogenesis and murine tumour growth by laminarin sulphate
| Autor: | J. Donaldson, D.H. Paper, R. Hoffman, H. Vogl |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1996 |
| Předmět: |
Cancer Research
Angiogenesis Basic fibroblast growth factor Molecular Sequence Data Neovascularization Physiologic Antineoplastic Agents Chick Embryo Biology Models Biological Neovascularization chemistry.chemical_compound Laminarin Mice In vivo Laminin Polysaccharides medicine Animals Fibrosarcoma Cells Cultured Matrigel Mice Inbred C3H Neovascularization Pathologic medicine.disease bacterial infections and mycoses Molecular biology Drug Combinations Oncology chemistry Carbohydrate Sequence Immunology biology.protein Cattle Proteoglycans Collagen Endothelium Vascular medicine.symptom Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | LAM S5 is a polysulphated derivative of the glucan laminarian that inhibits basic fibroblast growth factor (bFGF) binding and the bFGF-stimulated proliferation of fetal bovine heart endothelial (FBHE) cells. This report demonstrates that LAM S5 has anti-angiogenic activity, as shown by inhibition of tubule formation by endothelial cells cultured on Matrigel and inhibition of vascularisation of the chick chorioallantoic membrane. In addition, LAM S5 caused a tumour growth delay of the murine RIF-1 tumour of 2.6 days (P = 0.01). Images Figure 2 |
| Databáze: | OpenAIRE |
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