Dopamine D2 receptor gene variants: association and linkage studies in impulsive-addictive-compulsive behaviour
| Autor: | Robert Wood, David E. Comings, Thomas J H Chen, Kenneth Blum, Eric R. Braverman, Peter J. Sheridan |
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| Rok vydání: | 1995 |
| Předmět: |
Proband
Genetic Linkage media_common.quotation_subject Tourette syndrome Dopamine receptor D1 Dopamine receptor D3 Dopamine receptor D2 Genetics medicine Humans Obesity General Pharmacology Toxicology and Pharmaceutics Pathological media_common Receptors Dopamine D2 business.industry Mental Disorders Addiction Dopaminergic Genetic Variation medicine.disease Behavior Addictive Impulsive Behavior Compulsive Behavior business Clinical psychology |
| Zdroj: | Pharmacogenetics. 5:121-141 |
| ISSN: | 0960-314X |
| DOI: | 10.1097/00008571-199506000-00001 |
| Popis: | Drug and alcohol seeking behaviour has become a great global problem affecting millions of inhabitants with a cost to society in the billions. Dopaminergic reward pathways have frequently been implicated in the etiology of addictive behaviour. While other neurotransmitters have also been implicated, to date the only molecular genetic defect which has been found to associate with alcoholism, drug dependency, obesity, smoking, pathological gambling, attention-deficit-hyperactivity disorder (ADHD), Tourette syndrome, as well as other related compulsive behaviours, are the variants of the dopamine D2 receptor gene (DRD2). In this review of the available data on the subject, we report a number of independent meta-analyses that confirm an association of DRD2 polymorphisms and impulsive-additive-compulsive behaviour (IACB), which we have termed "Reward Deficiency Syndrome". While we agree that Meta-analyses of all exant studies support an association of variants of DRD2 and IACB, correct negative findings with alcoholism may be due to differences in assessing controls and inclusion/exclusion criteria for selection of diseased probands. |
| Databáze: | OpenAIRE |
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