Acupuncture As an Integrative Approach for the Treatment of Hot Flashes in Women With Breast Cancer: A Prospective Multicenter Randomized Controlled Trial (AcCliMaT)
| Autor: | Chiara Petrucci, Ermanno Rondini, Giorgia Razzini, Grazia Lesi, Laura Scaltriti, Alberto Botti, Fabrizio Artioli, Elisa Stivanello, Maria Bernadette Ligabue, Muriel Assunta Musti, Paolo Pandolfi, Pamela Mancuso, Francesco Cardini, Benedetta Benedetti |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Acupuncture Therapy Breast Neoplasms law.invention 03 medical and health sciences 0302 clinical medicine Breast cancer Randomized controlled trial law Hot flash Acupuncture Humans Medicine Prospective Studies 030212 general & internal medicine Aged Dry needling business.industry Random assignment Middle Aged medicine.disease Self Care Menopause Oncology 030220 oncology & carcinogenesis Hot Flashes Physical therapy Female medicine.symptom business Climacteric |
| Zdroj: | Journal of Clinical Oncology. 34:1795-1802 |
| ISSN: | 1527-7755 0732-183X |
| Popis: | Purpose To determine the effectiveness of acupuncture for the management of hot flashes in women with breast cancer. Patients and Methods We conducted a pragmatic, randomized controlled trial comparing acupuncture plus enhanced self-care versus enhanced self-care alone. A total of 190 women with breast cancer were randomly assigned. Random assignment was performed with stratification for hormonal therapy; the allocation ratio was 1:1. Both groups received a booklet with information about climacteric syndrome and its management to be followed for at least 12 weeks. In addition, the acupuncture group received 10 traditional acupuncture treatment sessions involving needling of predefined acupoints. The primary outcome was hot flash score at the end of treatment (week 12), calculated as the frequency multiplied by the average severity of hot flashes. The secondary outcomes were climacteric symptoms and quality of life, measured by the Greene Climacteric and Menopause Quality of Life scales. Health outcomes were measured for up to 6 months after treatment. Expectation and satisfaction of treatment effect and safety were also evaluated. We used intention-to-treat analyses. Results Of the participants, 105 were randomly assigned to enhanced self-care and 85 to acupuncture plus enhanced self-care. Acupuncture plus enhanced self-care was associated with a significantly lower hot flash score than enhanced self-care at the end of treatment (P < .001) and at 3- and 6-month post-treatment follow-up visits (P = .0028 and .001, respectively). Acupuncture was also associated with fewer climacteric symptoms and higher quality of life in the vasomotor, physical, and psychosocial dimensions (P < .05). Conclusion Acupuncture in association with enhanced self-care is an effective integrative intervention for managing hot flashes and improving quality of life in women with breast cancer. |
| Databáze: | OpenAIRE |
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