Pregnancy maintenance in ovariectomized rats with 16alpha,17alpha dihydroxyprogesterone derivatives and other progestogens
| Autor: | Michael Dephillipo, David M. Brennan, Aleck Borman, Euripides Yiacas, Leonard J. Lerner |
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| Rok vydání: | 1962 |
| Předmět: |
Male
medicine.medical_specialty Estrone Pregnancy Maintenance chemistry.chemical_compound Endocrinology Pregnancy Internal medicine medicine Animals Humans Castration Progesterone Algestone medicine.disease Acetonide Rats Orally active chemistry Ovariectomized rat Gestation Female Progestins Orchiectomy Acetophenone |
| Zdroj: | Endocrinology. 70 |
| ISSN: | 0013-7227 |
| Popis: | The acetophenone and acetonide derivatives of 16α,17α-dihydroxyprogesterone were compared with several other progestational steroids for maintenance of pregnancy activity in rats ovariectomized on day 8 of pregnancy. Both of these derivatives of 16α,17α-dihydroxyprogesterone, progesterone and 6α-methyl-17α-hydroxyprogesterone acetate, maintained pregnancy. 17α-Ethinyl-19- nortestosterone and 17α-hydroxyprogesterone caproate did not sustain gestation. Estrone enhanced the maintenance of pregnancy activity of progesterone and the acetophenone derivative of 16α,17α-dihydroxyprogesterone, the augmentation being greater in the latter compound. The acetophenone derivative of 16α,17α-dihydroxyprogesterone and 6α-methyl- 17α-hydroxyprogesterone acetate were orally active in preventing termination of pregnancy in castrated rats. |
| Databáze: | OpenAIRE |
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