Leukocyte filtration of the cardiotomy suction. Does it affect systemic leukocyte activation or pulmonary function?
| Autor: | Bronagh Walsh, Indie Bilkhoo, Richard Issitt, Adnan Mani, Jon Ball, David Voegeli |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Stimulation Suction 030204 cardiovascular system & hematology Leukocyte filtration Pulmonary Dysfunction Extracorporeal law.invention Pulmonary function testing 03 medical and health sciences 0302 clinical medicine law Internal medicine Leukocytes Cardiopulmonary bypass medicine Humans Radiology Nuclear Medicine and imaging Aged Advanced and Specialized Nursing Cardiopulmonary Bypass business.industry Cardiotomy suction General Medicine Respiratory Function Tests 030228 respiratory system Anesthesia Cardiology Female Cardiology and Cardiovascular Medicine business Safety Research |
| Zdroj: | Perfusion. 32:574-582 |
| ISSN: | 1477-111X 0267-6591 |
| DOI: | 10.1177/0267659117709922 |
| Popis: | Background: Cardiopulmonary bypass is thought to propagate a global systemic response through contact with the non-physiological surfaces of the extracorporeal circuit, leading to the stimulation of leukocytes, their adherence to endothelial cells and the release of cytotoxic molecules. This, in turn, has been shown to accelerate pulmonary injury. This study tested a new leukocyte-filtration system (RemoweLL) against a conventional system with no leukocyte-depleting capacity to determine the efficacy of the filtration system and its effects on pulmonary function. Methods: Thirty patients underwent coronary artery bypass graft surgery using either the RemoweLL filtration system (15 patients) or a conventional cardiopulmonary bypass circuit (15 patients). Data were collected on the total number of leukocytes, their differentiation and activation, using the leukocyte adhesion integrin CD11b as a surrogate marker. Pulmonary function was assessed using the Alveolar-arterial Oxygenation Index (AaOI) and patients were categorized using the Berlin definition of acute respiratory distress syndrome (ARDS). Results: Both groups showed significant increases in leukocyte numbers during CPB (pConclusions: Leukocyte filtration of cardiotomy suction did not influence total leukocyte counts or activation as measured by CD11b upregulation. Furthermore, no evidence could be found to suggest improved pulmonary function. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|