Right ventricular end-diastolic volume and outcomes in exacerbations of COPD
| Autor: | Simon A. Joosten, Paul Leong, Gayan Kathriachchige, John Troupis, Christian R Osadnik, Martin MacDonald, Kais Hamza, Paul T. King, Ahilan Kuganesan, Philip G. Bardin, Alexander Chua, Brian Ko, Kenneth K. Lau |
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| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
Body surface area Male COPD medicine.medical_specialty Framingham Risk Score business.industry Proportional hazards model Hazard ratio Stroke Volume medicine.disease Pulmonary Disease Chronic Obstructive Statistical significance Internal medicine Cohort medicine Cardiology Tetralogy of Fallot Humans Prospective Studies business Cohort study Retrospective Studies |
| Zdroj: | Respirology (Carlton, Vic.)REFERENCES. 27(1) |
| ISSN: | 1440-1843 |
| Popis: | Background and objective Right ventricular (RV) volumes are crucial outcome determinants in pulmonary diseases. Little is known about the associations of RV volumes during hospitalized acute exacerbations of chronic obstructive pulmonary disease (AECOPD). We aimed to ascertain associations of RV end-diastolic volume indexed to body surface area (RVEDVI) during hospitalized AECOPD and its relationship with mortality in long-term follow-up. Methods This is a prospective observational cohort study (December 2013-November 2019, ACTRN12617001562369) using dynamic retrospective ECG-gated computed tomography during hospitalized AECOPD. RVEDVI was defined as normal or high using Framingham Offspring Cohort values. Cox regression determined the prognostic relevance of RVEDVI for death. Results A total of 148 participants (70 ± 10 years [mean ± SD], 88 [59%] men) were included, of whom 75 (51%) had high RVEDVI. This was associated with more frequent hospital admissions in the 12 months before admission (52/75 [69%] vs. 38/73 [52%], p = 0.04) and higher breathlessness (modified Medical Research Council score, 2.9 ± 1.3 vs. 2.4 ± 1.2, p = 0.007). During follow-up, high RVEDVI was associated with greater mortality (log-rank p = 0.001). In univariable Cox regression, increasing RVEDVI was associated with higher mortality (hazard ratio [HR]: 1.02 per ml/m2 ; 95% CI: 1.01, 1.03; p = 0.001). In multivariable Cox regression, RVEDVI was independently associated with mortality (HR: 1.01 per ml/m2 ; 95% CI: 1.00, 1.03; p = 0.050) at a borderline significance level. Adding RVEDVI to three COPD mortality prediction systems improved model fit (pooled chi-square test [BODE: p = 0.05, ADO: p = 0.04, DOSE: p = 0.02]). Conclusion In patients with hospitalized AECOPD, higher RV end-diastolic volume was associated with worse acute clinical parameters and greater mortality. |
| Databáze: | OpenAIRE |
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