Bronchial asthma triggered by house dust mites in patients with local allergic rhinitis
| Autor: | Maria Jose Rodriguez, Maria Salas, Paloma Campo, Miguel Ángel Álvarez González, Cristobalina Mayorga, Carmen Rondon, Ana Molina, Natalia Pérez-Sánchez, Ibon Eguiluz-Gracia, Maria del Carmen Plaza-Serón, María José Torres |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Immunology Provocation test Tryptase medicine.disease_cause Immunoglobulin E Gastroenterology Bronchial Provocation Tests Atopy Young Adult 03 medical and health sciences 0302 clinical medicine Allergen Nonallergic rhinitis Internal medicine medicine Animals Humans Immunology and Allergy Antigens Dermatophagoides Skin Tests Asthma biology business.industry Pyroglyphidae Allergens Middle Aged medicine.disease Rhinitis Allergic respiratory tract diseases Eosinophils 030228 respiratory system biology.protein Female Methacholine Bronchial Hyperreactivity business 030215 immunology medicine.drug |
| Zdroj: | Allergy. |
| ISSN: | 1398-9995 0105-4538 |
| Popis: | BACKGROUND Over 30% of local allergic rhinitis (LAR) patients self-report bronchial symptoms suggestive of asthma, but the relationship between the allergen exposure and the bronchial symptoms has not been studied. OBJECTIVE To investigate whether a bronchial counterpart of LAR exists. METHODS Patients were classified by clinical history, skin prick test/serum specific IgE (sIgE), and nasal allergen provocation test (NAPT) into the LAR, allergic rhinitis (AR), and nonallergic rhinitis (NAR) phenotypes. Twenty-eight LAR, 18 AR, and 19 NAR patients self-reporting bronchial symptoms suggestive of asthma and 8 healthy controls (HC) were subjected to a methacholine test (MT) before (Visit 1) and 24 hours after (Visit 3) a bronchial provocation test with Dermatophagoides pteronyssinus (BPT-DP) (Visit 2). Induced sputum and peripheral blood obtained after each MT were analyzed for immune cell populations, tryptase, ECP, and sIgE. RESULTS A positive MT was found in 50% of LAR, 83.3% of AR, 57.89% of NAR, and 0% of HC individuals (P = 0.022 AR vs LAR) at V1. BPT-DP was positive in 8 LAR and 15 AR patients (28% vs 83.3%, P |
| Databáze: | OpenAIRE |
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