Mannose-Binding Lectin and Susceptibility to Schistosomiasis
| Autor: | Akeem A. Akindele, Peter G. Kremsner, Justin S. Antony, Olawumi R. Sina-Agbaje, A. O. Adeyeba, Hoang Van Tong, Thomas Engleitner, Eman Abou Ouf, Thirumalaisamy P. Velavan, Olusola Ojurongbe |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male haplotypes Adolescent Nigeria Schistosomiasis Mannose-Binding Lectin Cohort Studies Schistosomiasis haematobia Young Adult Major Articles and Brief Reports genotypes medicine Humans Immunology and Allergy Genetic Predisposition to Disease Parasites Allele Child Aged Mannan-binding lectin Schistosoma serum level Schistosoma haematobium biology Haplotype Middle Aged biology.organism_classification MBL deficiency medicine.disease MBL2 Infectious Diseases Case-Control Studies Child Preschool Immunology Female Ficolin |
| Zdroj: | The Journal of Infectious Diseases |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jit081 |
| Popis: | Background. Human ficolin 2 (encoded by FCN2) and mannose-binding lectin (encoded by MBL2) bind to specific pathogen-associated molecular patterns, activate the complement lectin cascade in a similar manner, and are associated with several infectious diseases. Our recently published study established certain FCN2 promoter variants and ficolin-2 serum levels as protective factors against schistosomiasis. Methods. We used the Nigerian cohort from our recently published study, which included 163 Schistosoma haematobium–infected individuals and 183 matched healthy subjects, and investigated whether MBL deficiency and MBL2 polymorphisms are associated with schistosomiasis. Results. MBL serum levels were significantly higher in controls and were associated with protection (P < .0001). The −550H minor allele was significantly associated with protection (P = .03), and the heterozygous genotypes −550HL were observed to confer protection (P = .03). The MBL2*HYPA haplotype was significantly associated with protection (P = .03), with significantly higher serum MBL levels in controls (P = .00073). The heterozygous 6-bp deletion in the promoter was observed to be a susceptibility factor in schistosomiasis (P = .03). Conclusions. In agreement with findings from our recently published study, the findings reported here support the observation that MBL is also associated with protection in schistosomiasis. |
| Databáze: | OpenAIRE |
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