| Přispěvatelé: |
[Ramírez-López,MT, Vázquez,M, Blanco,RN, Alén,F, Antón,M, Ouro,L, Rodríguez de Fonseca,F, Gómez de Heras,R] Departamento de Psicobiología, Facultad de Psicología, Universidad Complutense de Madrid, Madrid, Spain. [Vázquez,M, Degara,J, Suarez,J, Rodríguez de Fonseca,F] Unidad de Gestión Clínica de Salud Mental, Instituto IBIMA, Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain. [Bindila,L, Lomazzo,E, Hofmann,C, Lutz,B] Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., This work was supported by the Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (PI13/0226 to FR, CP12/03109 to JS and PSI-2012-35388 to RG), Red de Trastornos Adictivos (RD12/0028/0001 to FR), CIBERobn, Consejería de Economía, Innovación y Ciencia, Junta de Andalucía, UE/ERDF (PI45403, CTS-8221, CTS-433 to FR), Consejería de Salud, Junta de Andalucía (PI0232/2008, PI0029/2008, and SAS111224 to JS and FR), and the German Research Foundation DFG (FOR926, project CP1 to BL). MT RL has been funded by a FPU predoctoral fellowship of the Spanish Ministerio de Educación, Cultura y Deporte (AP-2009-0225), JS holds 'Miguel Servet' research contract from the National System of Health, ISCIII (grant numbers CP14/00173). |
| Popis: |
Journal Article; Exposure to unbalanced diets during pre-gestational and gestational periods may result in long-term alterations in metabolism and behavior. The contribution of the endocannabinoid system to these long-term adaptive responses is unknown. In the present study, we investigated the impact of female rat exposure to a hypercaloric-hypoproteic palatable diet during pre-gestational, gestational and lactational periods on the development of male offspring. In addition, the hypothalamic and hippocampal endocannabinoid contents at birth and the behavioral performance in adulthood were investigated. Exposure to a palatable diet resulted in low weight offspring who exhibited low hypothalamic contents of arachidonic acid and the two major endocannabinoids (anandamide and 2-arachidonoylglycerol) at birth. Palmitoylethanolamide, but not oleoylethanolamide, also decreased. Additionally, pups from palatable diet-fed dams displayed lower levels of anandamide and palmitoylethanolamide in the hippocampus. The low-weight male offspring, born from palatable diet exposed mothers, gained less weight during lactation and although they recovered weight during the post-weaning period, they developed abdominal adiposity in adulthood. These animals exhibited anxiety-like behavior in the elevated plus-maze and open field test and a low preference for a chocolate diet in a food preference test, indicating that maternal exposure to a hypercaloric diet induces long-term behavioral alterations in male offspring. These results suggest that maternal diet alterations in the function of the endogenous cannabinoid system can mediate the observed phenotype of the offspring, since both hypothalamic and hippocampal endocannabinoids regulate feeding, metabolic adaptions to caloric diets, learning, memory, and emotions. Yes |
