Expression of Claudin-1 and -7 in Clear Cell Renal Cell Carcinoma and Its Clinical Significance
| Autor: | Hong Il Shin, Choal Hee Park, Byung Hoon Kim, Chun Il Kim, Hye Ra Jung, Hyuk Soo Chang |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Pathology endocrine system diseases Urological Oncology urologic and male genital diseases digestive system Gastroenterology Renal cell carcinoma Internal medicine Medicine Clinical significance Stage (cooking) Claudin business.industry Claudin 1 Claudin 7 medicine.disease digestive system diseases female genital diseases and pregnancy complications Clear cell renal cell carcinoma T-stage Original Article business Body mass index Clear cell |
| Zdroj: | Korean Journal of Urology |
| ISSN: | 2005-6737 |
| DOI: | 10.4111/kju.2011.52.5.317 |
| Popis: | Purpose: We investigated the correlations between the expression of claudin-1 and claudin-7 in clear cell renal cell carcinoma (clear cell RCC) and clinical parameters. Materials and Methods: The subjects of this study were 119 patients with confirmed clear cell RCC between January 2000 and December 2007. Their RCC tissues were immunohistochemically stained for claudin-1 and claudin-7. The correlations between the expression of claudin and parameters such as sex, age, body mass index (BMI), tumor size, TNM stage, Furhman nuclear grade, postoperative distant metastasis, and cancer-specific survival were analyzed. Results: Among the total 119 subjects, claudin-1 was expressed in 18 (15.1%) and claudin-7 in 31 (26.1%). Claudin-1 was expressed in patients who were older (p=0.007), who had a greater tumor size (p=0.001), who had a higher pathologic T stage (p=0.009), who had preoperative distant metastasis (p=0.035), and who had a higher Furhman nuclear grade (p=0.004). Claudin-7 was expressed only in patients who had a higher Furhman nuclear grade (p=0.031). The risk of postoperative distant metastasis was associated with the expression of claudin-1 (p＜0.001) but not with the expression of claudin-7 (p=0.668). The expression of claudin-1 and -7 was not associated with cancer-specific survival (p＞0.05). Conclusions: In clear cell RCC, claudin-1 was expressed in patients who were older and who had a greater tumor size, who had higher T or M stages, and who had a higher Furhman nuclear grade. The expression of claudin-1 was associated with a higher risk of postoperative distant metastasis. |
| Databáze: | OpenAIRE |
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