Transcriptomic analysis reveals effects of fucoxanthin on intestinal glucose transport
| Autor: | Jing Li, Changhu Xue, Robert W. Li, Qingjuan Tang, Wanxiu Cao, Yao Xian Chin |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Fucoxanthin medicine.medical_treatment Medicine (miscellaneous) Transcriptomic analysis 03 medical and health sciences chemistry.chemical_compound Insulin resistance medicine TX341-641 Carotenoid Protein kinase B PI3K/AKT/mTOR pathway Glucose transporter chemistry.chemical_classification Nutrition and Dietetics Nutrition. Foods and food supply Insulin AMPK medicine.disease Intestine 030104 developmental biology chemistry Biochemistry Food Science |
| Zdroj: | Journal of Functional Foods, Vol 49, Iss, Pp 205-213 (2018) |
| ISSN: | 1756-4646 |
| DOI: | 10.1016/j.jff.2018.08.018 |
| Popis: | Fucoxanthin, one of carotenoid pigments from plants and algae, is known to regulate blood glucose and insulin levels. The mechanism of its hypoglycemic activity has drawn a lot of scientific interest in recent years. In this study, we investigated the effects of fucoxanthin on intestinal glucose transport using a murine model. Our data demonstrated that fucoxanthin was able to decrease blood glucose level and alleviate insulin resistance significantly. The results from RNA-seq based transcriptomic analysis, suggested that fucoxanthin acted as a key regulator in Insulin/PI3K/AKT/mTOR signaling and PKA/AMPK/mTOR signaling pathways. Moreover, fucoxanthin ingestion resulted in a significant reduction in the protein expression of intestinal glucose transporters, such as SGLT-1, and led to decreased translocation of GLUT-2, which contributed to the regulation of blood glucose level. Together, our findings provided a mechanistic insight into the regulatory effect of fucoxanthin on blood glucose. |
| Databáze: | OpenAIRE |
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