Remission of rheumatoid arthritis and potential determinants: a national multi-center cross-sectional survey

Autor: Sa-Li Zhang, Li-Jun Song, Fengxiao Zhang, Jing Yang, Min Feng, Xiaoyuan Wang, Bei Lai, Zhuoli Zhang, Bai-Lu Liu, Hongtao Jin, Liu Jt, Rong Yang, Yanhua Wang, Ci-Bo Huang, Cong Ye, Yan Wang, Xiao-Xia Li, Mei-Qiu Wei, Rong Shu, Li-Jun Wu, Ai-Xue Wang, Wen-Wen Sun, Haiying Chen, Ping Wei, Xiuru Wang, Ming Gao, Lan He, X. Li, Lu Gong, Liu Xm, Guanying Wang, Dan Ke, Ping Yu, Yan Zhang, Yuan An, Rong Mu, Zhanguo Li, Shaoxian Hu, Hui-Ming Yan, Jian-Li Xie, Hao Li, Bin Jia, Yin Su, Chun Li, Ping Zhu, Wang Jx, Zhen-Bin Li, Wang Lz, Yi Zhao, Xiaofeng Li, Yongfu Wang, Xin Lu, Shuling Han, Junfang Li, Lin Sun, Guangtao Li, Xiao-Min Liu, Jinying Lin, Li-na Chen, Liu Xy, Yong-Jing Cheng, Hui-Fang Guo, Cai-Hong Wang, Jie-Mei Tao, Yi Wang, Xiuyan Yang, Chun-Fang Zhang, Xiao-Xia Yu, Guochun Wang, Liufu Cui
Rok vydání: 2014
Předmět:
Zdroj: Clinical Rheumatology. 34:221-230
ISSN: 1434-9949
0770-3198
DOI: 10.1007/s10067-014-2828-3
Popis: The aim of this study is to investigate the remission rate of rheumatoid arthritis (RA) in China and identify its potential determinants. A multi-center cross-sectional study was conducted from July 2009 to January 2012. Data were collected by face-to-face interviews of the rheumatology outpatients in 28 tertiary hospitals in China. The remission rates were calculated in 486 RA patients according to different definitions of remission: the Disease Activity Score in 28 joints (DAS28), the Simplified Disease Activity Index (SDAI), the Clinical Disease Activity Index (CDAI), and the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Boolean definition. Potential determinants of RA remission were assessed by univariate and multivariate analyses. The remission rates of RA from this multi-center cohort were 8.6 % (DAS28), 8.4 % (SDAI), 8.2 % (CDAI), and 6.8 % (Boolean), respectively. Favorable factors associated with remission were: low Health Assessment Questionnaire (HAQ) score, absence of rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP), and treatment of methotrexate (MTX) and hydroxychloroquine (HCQ). Younger age was also predictive for the DAS28 and the Boolean remission. Multivariate analyses revealed a low HAQ score, the absence of anti-CCP, and the treatment with HCQ as independent determinants of remission. The clinical remission rate of RA patients was low in China. A low HAQ score, the absence of anti-CCP, and HCQ were significant independent determinants for RA remission.
Databáze: OpenAIRE
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