Fructose-1,6-bisphosphate aldolase (FBA)–a conserved glycolytic enzyme with virulence functions in bacteria: ‘ill met by moonlight’
| Autor: | Neil J. Oldfield, Karl G. Wooldridge, Fariza Shams, David P. J. Turner |
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| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
Protein moonlighting Fructose 1 6-bisphosphate Bacteria Virulence biology Aldolase A Plasminogen Plasma protein binding biology.organism_classification Biochemistry chemistry.chemical_compound Enzyme chemistry Fructose-Bisphosphate Aldolase biology.protein Humans Glycolysis Protein Binding |
| Zdroj: | Biochemical Society Transactions. 42:1792-1795 |
| ISSN: | 1470-8752 0300-5127 |
| DOI: | 10.1042/bst20140203 |
| Popis: | Moonlighting proteins constitute an intriguing class of multifunctional proteins. Metabolic enzymes and chaperones, which are often highly conserved proteins in bacteria, archaea and eukaryotic organisms, are among the most commonly recognized examples of moonlighting proteins. Fructose-1,6-bisphosphate aldolase (FBA) is an enzyme involved in the Embden–Meyerhof–Parnas (EMP) glycolytic pathway and in gluconeogenesis. Increasingly, it is also recognized that FBA has additional functions beyond its housekeeping role in central metabolism. In the present review, we summarize the current knowledge of the moonlighting functions of FBA in bacteria. |
| Databáze: | OpenAIRE |
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