Cortical spreading depression reduces paraventricular activation induced by hippocampal neostigmine injection
| Autor: | Marcellino Monda, V. De Luca, A. Sullo, Andrea Viggiano |
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| Přispěvatelé: | Monda, Marcellino, Viggiano, A, Sullo, A, DE LUCA, V. |
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Colon Central nervous system Hippocampus Hippocampal formation Body Temperature Injections Rats Sprague-Dawley Adipose Tissue Brown Internal medicine Brown adipose tissue cytology/physiology medicine Animals Molecular Biology Neurons Chemistry General Neuroscience Cortical Spreading Depression Brown Adipose Tissue physiology Animals Body Temperature drug effects/physiology Colon physiology Cortical Spreading Depression physiology Electrophysiology Hippocampus drug effects Injections Male Neostigmine pharmacology Neurons physiology Paraventricular Hypothalamic Nucleus cytology/physiology Rats Rats Sprague-Dawley Neostigmine Rats Electrophysiology medicine.anatomical_structure Endocrinology drug effects/physiology nervous system Cerebral cortex Hypothalamus Cortical spreading depression drug effects physiology Neurology (clinical) pharmacology Developmental Biology medicine.drug Paraventricular Hypothalamic Nucleus |
| Popis: | The firing rate of the neurons of the hypothalamic paraventricular nucleus, the temperatures of the interscapular brown adipose tissue and of the colon (TIBAT and Tc) were monitored in 24 urethane-anesthetized male Sprague-Dawley rats divided into four groups. These variables were measured before and after hippocampal injection of neostigmine (5x10(-7) mol) in the 1st and 2nd groups or of saline in the 3rd and 4th groups. The hippocampal injection was preceded by cortical spreading depression in the 1st and 3rd groups, while the cortical depression was not induced in the 2nd and 4th groups. The results show an increase of firing rate, TIBAT and Tc after neostigmine injection in the rats without cortical depression. Cortical spreading depression significantly reduces these enhancements. These findings demonstrate that: (1) the paraventricular nucleus plays a significant role in the hyperthermia induced by neostigmine injection into the hippocampus; and (2) the cerebral cortex is involved in the control of the paraventricular activity. |
| Databáze: | OpenAIRE |
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