Improving the effects of ketogenic diet therapy in children with drug-resistant epilepsy
| Autor: | Xinguo Lu, Jia-Lun Wen, Yaoye Wang, Jianxiang Liao, Sufang Lin, Wenjing Wei, Bing Li, Zhitian Xiao, Rongrong Yang, Dongfang Zou, Mei Yu, Man Zhang, Dezhi Cao, Jing-Hua Ye, Li Chen, Haili Chen, Yan Hu, Tieshuan Huang |
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| Rok vydání: | 2022 |
| Předmět: |
Drug Resistant Epilepsy
medicine.medical_specialty Side effect medicine.medical_treatment Epilepsy Seizures Internal medicine medicine Humans Child Adverse effect Retrospective Studies business.industry Retrospective cohort study General Medicine Retention rate medicine.disease Treatment Outcome Pharmaceutical Preparations Neurology Epilepsy in children Cohort Neurology (clinical) Diet Ketogenic business Ketogenic diet |
| Zdroj: | Seizure. 94:183-188 |
| ISSN: | 1059-1311 |
| DOI: | 10.1016/j.seizure.2021.10.021 |
| Popis: | PURPOSE To evaluate the retention rate, efficacy, and safety of ketogenic diet therapy for drug-resistant epilepsy in children and compare the results with those of a previous cohort at our institution. METHODS A total of 634 children with drug-resistant epilepsy were included in this retrospective study. Patients were categorized into two groups. The previous cohort was included as a control group and included 317 children assessed between 2004 and 2011, whereas the current group included 317 children assessed between 2015 and 2019. The control group was provided care as usual, and the current group additionally adopted the goal and long-term management strategy. Outcomes were measured with respect to retention rate, seizure reduction, and adverse reaction. RESULTS Patient demographics were consistent between both cohorts. Compared to the past ten years, the retention rate significantly increased over time (3 months: 62.8% vs. 82.0%, p |
| Databáze: | OpenAIRE |
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