Antipsychotic properties of new N-(4-substituted-1-piperazinylethyl)- and N-(4-substituted-1-piperidinylethyl)-phthalimides
| Autor: | Khalid A. Al-Rashood, Abdul Azim E. Madani, Ali A. Mustafa, Abdulqader A. Alhaider, H. A. El-Obeid, O. T. Ginawi |
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| Rok vydání: | 1988 |
| Předmět: |
Male
medicine.medical_specialty Side effect Apomorphine Chemical Phenomena medicine.medical_treatment Guinea Pigs Pharmaceutical Science Phthalimides Catalepsy Pharmacology Motor Activity Piperazines Lethal Dose 50 Mice Piperidines Internal medicine medicine Haloperidol Animals Antipsychotic Chemistry Parasympatholytics Rats Inbred Strains medicine.disease Rats Endocrinology Mechanism of action Dopamine receptor Female medicine.symptom Stereotyped Behavior Sulpiride medicine.drug Antipsychotic Agents Pergolide |
| Zdroj: | Journal of pharmaceutical sciences. 77(10) |
| ISSN: | 0022-3549 |
| Popis: | A series of N -(4-phenyl- and 4-pyridyl-1-piperazinylethyl)-and N -(4-phenyl-1-piperidinylethyl)-phthalimides were synthesized and tested for antipsychotic activity. All compounds suppressed the spontaneous motor activity and the apomorphine-induced climbing in mice and pergolide-induced locomotor activity in rats, demonstrating psychotropic properties equal to the corresponding properties of sulpiride. Although the compounds, like sulpiride, were less potent than haloperidol in blocking the locomotor activites, they caused no catalepsy, a major side effect following treatment with conventional antipsychotic agents. It is likely that the new compounds produce their neuroleptic activities through inhibition of limbic dopamine receptors. |
| Databáze: | OpenAIRE |
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