STUDIES ON A NEW METABOLITE AND ITS OXIDATION IN THE PRESENCE OF ASCORBIC ACID

Autor:	Frederick Bernheim, Dorothea B. Fitzgerald, Karl M. Wilbur
Rok vydání:	1947
Předmět:	Catechol Chromatography Physiology Cyanide Metabolite Catechols Proteins chemistry.chemical_element Ascorbic Acid Tyramine Kidney Ascorbic acid Oxygen Article Catalysis Rats chemistry.chemical_compound chemistry Biochemistry Animals Gallic acid Oxidation-Reduction
Zdroj:	The Journal of General Physiology
ISSN:	1540-7748 0022-1295
DOI:	10.1085/jgp.31.2.195
Popis:	1. A number of tissues, in particular, brain, liver, and kidney, incubated aerobically in vitro as slices or ground suspensions produce a compound which combines with p-aminobenzoic acid in acid solution to form a yellow color. 2. A study of this reaction in rat brain has shown that this compound can be produced when washed boiled brain protein is incubated aerobically with ascorbic acid. The latter acts as a catalyst to break the linkage between the protein and the compound. Oxygen is taken up in the process. 3. A number of aromatic hydroxy compounds such as epinephrine and catechol inhibit the reaction. Cyanide has little or no effect. No reaction occurs anaerobically. 4. The occurrence of the reaction in some animals has been described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c15a03ed9093d61babbbe8f62ba4ee https://doi.org/10.1085/jgp.31.2.195 Zobrazit plný text záznamu