Cardiovascular and hidroelectrolytic changes in rats fed with high-fat diet
| Autor: | Rafaela Moreira Barbosa, Debora S. A. Colombari, Laurival A. De Luca, Jessica M. Sa, Eduardo Colombari, José Vanderlei Menani |
|---|---|
| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Calorie Sodium Drinking chemistry.chemical_element Blood Pressure Diet High-Fat Rats Sprague-Dawley 03 medical and health sciences Behavioral Neuroscience Eating 0302 clinical medicine Internal medicine Renin–angiotensin system Renal excretion medicine Animals Obesity 030304 developmental biology Injections Intraventricular Arterial pressure 0303 health sciences Water intake business.industry Angiotensin II digestive oral and skin physiology Water-Electrolyte Balance Rats Atropine Endocrinology medicine.anatomical_structure Blood pressure chemistry Ventricle Renal physiology Hypertension business 030217 neurology & neurosurgery hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2019-10-06T17:15:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-11-05 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Obesity activates the renin-angiotensin and sympathetic systems facilitating hypertension and changes in the hydroelectrolytic balance. In the present study, in rats fed with high-fat diet (HFD), we investigated daily water intake and urinary excretion, prandial consumption of water and the changes in blood pressure and water intake to intracerebroventricular (icv) angiotensin II (ANG II). Male Holtzman rats (290–320 g) were fed with standard diet (SD, 11% calories from fat) or HFD (45% calories from fat) for 6 weeks. Part of the animals received a stainless steel cannula in the lateral ventricle (LV) at the 6th week after the beginning of the diets and the experiments were performed at the 7th week. The pressor effect, but not the dipsogenic response to acute icv injection of ANG II, was potentiated in the HFD rats. Daily water intake and urinary volume were reduced in rats fed with HFD with no significant changes in sodium excretion. Prandial water consumption was also reduced in rats ingesting HFD, an effect almost totally reverted blocking salivation with atropine. These results show a potentiation of the pressor response to icv ANG II in HFD-fed rats, without changing icv ANG II-induced water intake. In addition, prandial and daily water intake and urinary volume were reduced in HFD-fed rats, without changing sodium excretion. Salivation in rats ingesting HFD may play a role in the reduced prandial and daily water intake. Department of Physiology and Pathology School of Dentistry UNESP - São Paulo State University Department of Physiology and Pathology School of Dentistry UNESP - São Paulo State University FAPESP: 2015/234677 FAPESP: 2017/10762-6 CNPq: 308099/2017-6 CNPq: 425586/2016-2 |
| Databáze: | OpenAIRE |
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