Practice survey on the use of vancomycin in pediatrics in the New Aquitaine region and guidelines of learned societies
| Autor: | E. Pauquet, S. Veluzat, J. Sarlangue |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Pediatrics Dose Adolescent Continuous infusion Inappropriate Prescribing Drug Administration Schedule 03 medical and health sciences 0302 clinical medicine Vancomycin 030225 pediatrics medicine Humans Trough Concentration Neonatology Dosing Practice Patterns Physicians' Child business.industry Drug Administration Routes Infant Newborn Infant Bacterial Infections Serum concentration Anti-Bacterial Agents Child Preschool Health Care Surveys Pediatrics Perinatology and Child Health Practice Guidelines as Topic France Guideline Adherence business Hospital Units medicine.drug |
| Zdroj: | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie. 27(4) |
| ISSN: | 1769-664X |
| Popis: | Introduction Vancomycin is an old antibiotic whose use is still being debated today. The objective of this work was to establish an inventory of the use of vancomycin in the various pediatric and neonatal hospital services in the New Aquitaine region. Materials and methods A declaratory practice survey was conducted in 49 pediatric and neonatal hospital units. These practices were compared with the guidelines of several learned societies. Results A total of 36 responses could be analyzed: 12 units (33%) used vancomycin in discontinuous administration, 18 (50%) had opted for continuous infusion, and six used it in both modalities (17%). The reported dosages were highly variable. Blood tests were performed by 26 units (72%), but the target values of the trough serum concentration were also highly variable. After dosing, all units reported adjusting the dosage and re-dosing after modification (26/26). Finally, 21 units (58%) reported taking into account the MIC of the possibly isolated bacterium. Conclusion Our study shows that vancomycin is used in very different ways from one unit to another, within the same region, including in ways not recommended by the main learned societies. Much work remains to be done to determine the optimal dosages of vancomycin in pediatrics, to set the serum trough concentration of vancomycin values, and to determine whether continuous infusion use is comparable to discontinuous administration in terms of efficacy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect