The Successful Treatment of a Cord Blood Transplant Recipient with Varicella Zoster Virus Meningitis, Radiculitis and Myelitis with Foscarnet
| Autor: | Tomoya Muto, Naoya Mimura, Emi Togasaki, Yuhei Nagao, Ryo Shimizu, Tohru Iseki, Chika Kawajiri, Shio Sakai, Chiaki Nakaseko, Emiko Sakaida, Shokichi Tsukamoto, Masahiro Takeuchi, Chikako Ohwada, Yusuke Takeda |
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| Rok vydání: | 2017 |
| Předmět: |
Foscarnet
Herpesvirus 3 Human medicine.medical_treatment viruses Myelitis Acyclovir Graft vs Host Disease Case Report Hematopoietic stem cell transplantation medicine.disease_cause Antiviral Agents Herpes Zoster 03 medical and health sciences myelitis 0302 clinical medicine Radiculitis Internal Medicine medicine Humans Transplantation Homologous varicella zoster virus integumentary system business.industry Varicella zoster virus Hematopoietic Stem Cell Transplantation virus diseases meningitis foscarnet General Medicine biochemical phenomena metabolism and nutrition medicine.disease Meningitis Viral Transplantation Cord blood Immunology business Meningitis 030217 neurology & neurosurgery 030215 immunology medicine.drug |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 |
| Popis: | Infections of the central nervous system (CNS) with varicella zoster virus (VZV) is a rare occurrence after allogeneic hematopoietic stem cell transplantation. We herein report a case of VZV meningitis, radiculitis and myelitis that developed 8 months after cord blood transplantation, shortly after the cessation of cyclosporine and low-dose acyclovir. Although treatment with acyclovir did not achieve a satisfactory response, the patient was successfully treated with foscarnet. Our report indicates that VZV infection should be considered in allo-hematopoietic stem cell transplantation (HSCT) patients with CNS symptoms and that foscarnet may be effective for the treatment of acyclovir-resistant VZV infections of the CNS. The development of optimal prophylactic strategies and vaccination schedules may eradicate post-transplant VZV disease. |
| Databáze: | OpenAIRE |
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