Diverse Community Structures in the Neuronal-Level Connectome of the Drosophila Brain
| Autor: | Ting-Yuan Wang, Chi-Tin Shih, Ta-Shun Su, Chih-Chen Chen, Yen-Jen Lin, Cheng-Te Wang, Ann-Shyn Chiang, Chung-Chuang Lo |
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| Rok vydání: | 2019 |
| Předmět: |
Modularity (biology)
Olfaction Biology 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Connectome Animals 0501 psychology and cognitive sciences Neurons General Neuroscience 05 social sciences Information processing Brain biology.organism_classification Drosophila melanogaster Brain size Nerve Net Centrality Neuroscience 030217 neurology & neurosurgery Software Information Systems Information integration |
| Zdroj: | Neuroinformatics. 18(2) |
| ISSN: | 1559-0089 |
| Popis: | Drosophila melanogaster is one of the most important model animals in neurobiology owing to its manageable brain size, complex behaviour, and extensive genetic tools. However, without a comprehensive map of the brain-wide neural network, our ability to investigate brain functions at the systems level is seriously limited. In this study, we constructed a neuron-to-neuron network of the Drosophila brain based on the 28,573 fluorescence images of single neurons in the newly released FlyCircuit v1.2 (http://www.flycircuit.tw) database. By performing modularity and centrality analyses, we identified eight communities (right olfaction, left olfaction, olfactory core, auditory, motor, pre-motor, left vision, and right vision) in the brain-wide network. Further investigation on information exchange and structural stability revealed that the communities of different functions dominated different types of centralities, suggesting a correlation between functions and network structures. Except for the two olfaction and the motor communities, the network is characterized by overall small-worldness. A rich club (RC) structure was also found in this network, and most of the innermost RC members innervated the central complex, indicating its role in information integration. We further identified numerous loops with length smaller than seven neurons. The observation suggested unique characteristics in the information processing inside the fruit fly brain. |
| Databáze: | OpenAIRE |
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