Non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational study
| Autor: | Jonathan H Williams, Jeffrey L. Seeburger, A. David Smith, Aimee Dallob, William Z. Potter, Omar F Laterza, Gordon K. Wilcock |
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| Rok vydání: | 2010 |
| Předmět: |
Oncology
medicine.medical_specialty Neurology business.industry Cognitive Neuroscience Research Cognitive score Clinical Neurology Cognition Disease Cerebrospinal fluid Internal medicine mental disorders medicine Biomarker (medicine) Observational study sense organs Neurology (clinical) Cognitive impairment business Neuroscience |
| Zdroj: | Alzheimer's Research & Therapy |
| ISSN: | 1758-9193 |
| Popis: | INTRODUCTION: Levels of cerebrospinal fluid (CSF) β-amyloid (Aβ) and Tau proteins change in Alzheimer's disease (AD). We tested if the relationships of these biomarkers with cognitive impairment are linear or non-linear. METHODS: We assessed cognitive function and assayed CSF Aβ and Tau biomarkers in 95 non-demented volunteers and 97 AD patients. We then tested non-linearities in their inter-relations. RESULTS: CSF biomarkers related to cognitive function in the non-demented range of cognition, but these relations were weak or absent in the patient range; Aβ1-40's relationship was biphasic. CONCLUSIONS: Major biomarker changes precede clinical AD and index cognitive impairment in AD poorly, if at all. |
| Databáze: | OpenAIRE |
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