DETERMINANTS OF IMMUNOLOGICAL RESPONSIVENESS IN RECURRENT SPONTANEOUS ABORTION
| Autor: | R.M.R. Barnes, Peter M. Johnson, W.J.A. Francis, C.A. Hart |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
Abortion Habitual Immunology Congenital cytomegalovirus infection Cross Reactions Abortion Antibodies Viral Isoantibodies Immune system Antigen HLA Antigens Pregnancy Immune Tolerance medicine Immunology and Allergy Humans Antilymphocyte Serum Transplantation biology business.industry Incidence (epidemiology) Obstetrics and Gynecology medicine.disease Abortion Incomplete Spermatozoa Titer Reproductive Medicine Blood Group Antigens Etiology biology.protein Female Antibody business |
| Zdroj: | Transplantation. 38:280-283 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/00007890-198409000-00016 |
| Popis: | A defined group of 20 women suffering recurrent spontaneous abortions of unknown etiology was studied for determinants relevant to immune responsiveness. A low prevalence of serum anti-CMV antibodies (35%; cf, 65% in controls)--but not anti-herpes-simplex-virus or Epstein-Barr virus antibodies--was noted. Only two (10%) of these women had lymphocytotoxic antibodies following their repeated pregnancies; low titer anti-sperm antibody was present in two other of these women. Whereas there was no significantly increased sharing of HLA-A or -B antigens within these couples compared with controls, there was an increased incidence of apparent HLA-B antigen homozygosity in the women. These data indicate a degree of immunological nonresponsiveness both to cytomegalovirus and to cell-surface alloantigens in habitually aborting women and, together with MLC data, provide further evidence that immunogenetic events may be relevant to reproductive success. |
| Databáze: | OpenAIRE |
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