Induction of collagenase synthesis in chondrocytes by a factor synthesized by inflamed synovial tissue
| Autor: | Joseph C. Nolan, M. Jane Landes, Arnold L. Oronsky, Suresh S. Kerwar, Susan C. Ridge |
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| Rok vydání: | 1994 |
| Předmět: |
Cartilage
Articular Immunology In Vitro Techniques Biology Cycloheximide Toxicology Chondrocyte chemistry.chemical_compound Biosynthesis medicine Animals Pharmacology (medical) Pharmacology Synovitis Lagomorpha Cartilage Trypsin biology.organism_classification Molecular biology Kinetics Microbial Collagenase medicine.anatomical_structure chemistry Enzyme Induction Protein Biosynthesis Collagenase Rabbits Synovial membrane medicine.drug |
| Zdroj: | Agents and Actions. 43:206-210 |
| ISSN: | 1420-908X 0065-4299 |
| DOI: | 10.1007/bf01986690 |
| Popis: | Rabbit inflamed synovial tissue grown in culture synthesizes a factor that induces collagenase synthesis in chondrocytes and in cartilage. Synthesis of this factor by the synovial tissue is inhibited by cycloheximide but not by indomethacin. The factor has an apparent molecular weight of 30,000, is stable to heat and to trypsin treatment but is inactivated by acid. Induction of collagenase synthesis in chondrocytes occurs after a lag period of 6 hours. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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