Oscillations in cortico-basal ganglia circuits: implications for Parkinson’s disease and other neurologic and psychiatric conditions
| Autor: | Per Petersson, Pär Halje, Juan J. Mariman, Claudio Da Cunha, Ivani Brys, Romulo Fuentes |
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| Rok vydání: | 2019 |
| Předmět: |
Cerebral Cortex
Dystonia medicine.medical_specialty Psychosis Epilepsy Parkinson's disease Essential tremor Physiology business.industry General Neuroscience Electric Stimulation Therapy Parkinson Disease medicine.disease Basal Ganglia Schizophrenia Cortical Excitability Basal ganglia Animals Humans Medicine Premovement neuronal activity business Psychiatry |
| Zdroj: | Journal of Neurophysiology. 122:203-231 |
| ISSN: | 1522-1598 0022-3077 |
| Popis: | Cortico-basal ganglia circuits are thought to play a crucial role in the selection and control of motor behaviors and have also been implicated in the processing of motivational content and in higher cognitive functions. During the last two decades, electrophysiological recordings in basal ganglia circuits have shown that several disease conditions are associated with specific changes in the temporal patterns of neuronal activity. In particular, synchronized oscillations have been a frequent finding suggesting that excessive synchronization of neuronal activity may be a pathophysiological mechanism involved in a wide range of neurologic and psychiatric conditions. We here review the experimental support for this hypothesis primarily in relation to Parkinson’s disease but also in relation to dystonia, essential tremor, epilepsy, and psychosis/schizophrenia. |
| Databáze: | OpenAIRE |
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