Comparative study of normotensive and hypertensive nitric oxide synthase inhibitors on morphine withdrawal syndrome in rats
| Autor: | S.Y. Duval, R. de Vries, M.R. Dzoljic, Susanne L.T. Cappendijk |
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| Rok vydání: | 1995 |
| Předmět: |
Diarrhea
Male medicine.medical_specialty Arginine (+)-Naloxone Nitric Oxide Irritability Nitric oxide chemistry.chemical_compound Internal medicine medicine Animals Rats Wistar Dose-Response Relationship Drug Morphine biology Naloxone business.industry General Neuroscience Rats Substance Withdrawal Syndrome Nitric oxide synthase Endocrinology chemistry Enzyme inhibitor Anesthesia biology.protein Amino Acid Oxidoreductases Nitric Oxide Synthase medicine.symptom Licking business medicine.drug |
| Zdroj: | Neuroscience Letters. 183:67-70 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/0304-3940(94)11116-z |
| Popis: | The effects of the normotensive, mainly centrally active nitric oxide synthase (NOS) inhibitor 7-nitro indazole and the hypertensive drug NG-nitro- l -arginine, which blocks both the endothelial and the central NOS, have been examined on naloxone-precipitated withdrawal in morphine-dependent rats. Both drugs attenuated the same withdrawal signs (teeth-chattering, penile licking, diarrhoea, chewing, wet-dog shakes, grooming), while other signs remained unaffected (rearing, jumping, ptosis, rhinorrhoea, irritability on touch). These findings indicate that mainly central (but not endothelial) nitric oxide is involved in the expression of some opioid withdrawal symptoms. |
| Databáze: | OpenAIRE |
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