Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial
| Autor: | Zee, J. van der, González González, D., Rhoon, G.C. van, Dijk, J.D.P. van, Putten, W.L.J. van, Hart, A.A.M., Hoogenraad, W.J. |
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| Rok vydání: | 2000 |
| Předmět: |
Cervical cancer
Hyperthermia medicine.medical_specialty Bladder cancer Intention-to-treat analysis business.industry medicine.medical_treatment Cancer Rectum General Medicine medicine.disease Experimentele radiotherapie en neuro-oncologie Surgery Radiation therapy medicine.anatomical_structure medicine business Cervix Experimental radiotherapy and neuro-oncology |
| Zdroj: | The Lancet (London), 355, pp. 1119-1125 The Lancet (London), 355, 1119-1125 |
| ISSN: | 0140-6736 |
| Popis: | Summary Background Local-control rates after radiotherapy for locally advanced tumours of the bladder, cervix, and rectum are disappointing. We investigated the effect of adding hyperthermia to standard radiotherapy. Methods The study was a prospective, randomised, multicentre trial. 358 patients were enrolled from 1990 to 1996, in cancer centres in the Netherlands, who had bladder cancer stages T2, T3, or T4, N0, M0, cervical cancer stages IIB, IIIB, or IV, or rectal cancer stage M0–1 were assessed. Patients were randomly assigned radiotherapy (median total dose 65 Gy) alone (n=176) or radiotherapy plus hyperthermia (n=182). Our primary endpoints were complete response and duration of local control. We did the analysis by intention to treat. Findings Complete-response rates were 39% after radiotherapy and 55% after radiotherapy plus hyperthermia (p Interpretation Hyperthermia in addition to standard radiotherapy may be especially useful in locally advanced cervical tumours. Studies of larger numbers of patients are needed for other pelvic tumour sites before practical recommendations can be made. |
| Databáze: | OpenAIRE |
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