Interspecies Transmission of Reassortant Swine Influenza A Virus Containing Genes from Swine Influenza A(H1N1)pdm09 and A(H1N2) Viruses

Autor: Alejandro Núñez, Pauline M. van Diemen, Bethany J. Nash, Vivien J Coward, Sharon M. Brookes, Helen Everett, Ian H. Brown, Brandon Z. Londt, Michael D. Kelly
Rok vydání: 2020
Předmět:
Male
Interspecies Transmission of Reassortant Swine Influenza A Virus Containing Genes from Influenza A(H1N1)pdm09 and A(H1N2) Viruses
Genes
Viral
Swine
Epidemiology
viruses
lcsh:Medicine
reassortant virus
medicine.disease_cause
influenza virus
influenza A(H1N1)pdm09 virus
Influenza A Virus
H1N1 Subtype
0302 clinical medicine
Zoonoses
Influenza A virus
030212 general & internal medicine
Swine Diseases
biology
pathogenesis
pigs
Infectious Diseases
Gene cassette
Enzootic
influenza
Reassortant Viruses
Microbiology (medical)
030231 tropical medicine
Virulence
Hemagglutinin (influenza)
interspecies transmission
Virus
lcsh:Infectious and parasitic diseases
respiratory infections
03 medical and health sciences
Influenza A Virus
H1N2 Subtype
Influenza
Human
medicine
Animals
Humans
lcsh:RC109-216
Host (biology)
Research
lcsh:R
Ferrets
Virology
United Kingdom
swine influenza A(H1N2) virus
biology.protein
Neuraminidase
Zdroj: Emerging Infectious Diseases
Emerging Infectious Diseases, Vol 26, Iss 2, Pp 273-281 (2020)
ISSN: 1080-6059
1080-6040
DOI: 10.3201/eid2602.190486
Popis: Influenza A(H1N1)pdm09 (pH1N1) virus has become established in swine in the United Kingdom and currently co-circulates with previously enzootic swine influenza A virus (IAV) strains, including avian-like H1N1 and human-like H1N2 viruses. During 2010, a swine influenza A reassortant virus, H1N2r, which caused mild clinical disease in pigs in the United Kingdom, was isolated. This reassortant virus has a novel gene constellation, incorporating the internal gene cassette of pH1N1-origin viruses and hemagglutinin and neuraminidase genes of swine IAV H1N2 origin. We investigated the pathogenesis and infection dynamics of the H1N2r isolate in pigs (the natural host) and in ferrets, which represent a human model of infection. Clinical and virologic parameters were mild in both species and both intraspecies and interspecies transmission was observed when initiated from either infected pigs or infected ferrets. This novel reassortant virus has zoonotic and reverse zoonotic potential, but no apparent increased virulence or transmissibility, in comparison to pH1N1 viruses.
Databáze: OpenAIRE
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