Platelet-rich fibrin as a treatment option for osteoradionecrosis: A literature review
| Autor: | Matthieu Schmittbuhl, Philippe Harris, Robert Durand, Ryma Kabir |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Osteoradionecrosis medicine.medical_treatment Cochrane Library 03 medical and health sciences 0302 clinical medicine Internal medicine Platelet-Rich Fibrin medicine Humans 030223 otorhinolaryngology business.industry Head and neck cancer Treatment options 030206 dentistry medicine.disease Platelet-rich fibrin Adjunct Radiation therapy Clinical trial Otorhinolaryngology Head and Neck Neoplasms Surgery Oral Surgery business Neck |
| Zdroj: | Journal of stomatology, oral and maxillofacial surgery. 123(3) |
| ISSN: | 2468-7855 |
| Popis: | The aim of this review is to establish the usefulness and effectiveness of using platelet-rich fibrin (PRF) in the treatment of osteoradionecrosis (ORN) lesions. A review of the literature was performed using keywords through the PubMed-Medline and Cochrane Library search engine. Inclusion criteria were: (1) original publication in either the French or the English language, (2) studies conducted in humans, (3) presence of ORN lesions following head and neck radiotherapy (RT), (4) use of PRF or derivates in the treatment of ORN lesions, (5) clinical variables and outcomes mentioned in the study. Overall, four case reports were retained. Two publications were removed from the initial seven results after application of the inclusion criteria. A recent randomised clinical trial was not considered since the group analysed the effectiveness of leukocyte-enriched Plasmas-Rich-Fibrin (LPRF) in preventing ORN, but not in treating it. Therefore, four publications were retained for analysis. Results suggest that using PRF as an adjunct to surgical therapy is beneficial in treating ORN lesions although no controlled studies were found. Therefore, additional controlled clinical studies are warranted to better define the effectiveness and recommendation of this approach. |
| Databáze: | OpenAIRE |
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