Highly Increased Levels of Inter-α-inhibitor Heavy Chain 4 (ITIH4) in Autoimmune Cholestatic Liver Diseases
| Autor: | Tea Lund Laursen, Lars Bossen, Rasmus Pihl, Anne Troldborg, Thomas Damgaard Sandahl, Annette Gudmann Hansen, Trine Folserass, Mette Vesterhus, Henning Grønbæk, Steffen Thiel |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Laursen, T L, Bossen, L, Pihl, R, Troldborg, A, Sandahl, T D, Hansen, A G, Folserass, T, Vesterhus, M, Gronbaek, H & Thiel, S 2022, ' Highly Increased Levels of Inter-α-inhibitor Heavy Chain 4 (ITIH4) in Autoimmune Cholestatic Liver Diseases ', Journal of clinical and translational hepatology, vol. 10, no. 5, pp. 796–802 . https://doi.org/10.14218/JCTH.2021.00515 Laursen, T L, Bossen, L, Pihl, R, Troldborg, A, Sandahl, T D, Hansen, A G, Folserass, T, Vesterhus, M, Grønbæk, H & Thiel, S 2022, ' Highly Increased Levels of Inter-α-inhibitor Heavy Chain 4 (ITIH4) in Autoimmune Cholestatic Liver Diseases ', Journal of clinical and translational hepatology, vol. 10, no. 5, pp. 796-802 . https://doi.org/10.14218/JCTH.2021.00515 |
| Popis: | Background and Aims: There is an unmet need for new biomarkers to improve diagnostics and prognostics in primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). Inter-α-inhibitor heavy chain 4 (ITIH4) is an abundant, liver-produced protein, and its synthesis may be altered in liver diseases. We investigated whether ITIH4 plasma concentrations were affected in PBC and PSC patients.Methods: We developed an immunoassay specific for ITIH4 and determined ITIH4 plasma concentrations in 66 PBC, 126 PSC, 92 autoimmune hepatitis (AIH), 67 chronic hepatitis C (CHC), 33 alcoholic hepatitis (AH) patients and 138 healthy controls (HCs). Hepatic ITIH4 expression was investigated by immunohistochemistry in PBC.Results: The mean plasma concentration of ITIH4 was almost doubled in PBC [409 µg/mL (95% CI: 388-431)] and 35% higher in PSC [308 µg/mL, (95% CI: 296-319)] compared with HCs [226 µg/mL (95% CI: 221-231); pConclusions: The plasma concentration of ITIH4 was highly elevated in patients with PBC and PSC, suggesting that ITIH4 should be further investigated as a biomarker in cholestatic liver disease. |
| Databáze: | OpenAIRE |
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