S-MDM4 mRNA overexpression indicates a poor prognosis and marks a potential therapeutic target in chronic lymphocytic leukemia
| Autor: | Ling Liu, Lei Fan, Li-Na Zhang, Wei Xu, Zhi-Jian Zou, Cheng Fang, Shu Yang, Jianyong Li |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Cancer Research Chronic lymphocytic leukemia Antineoplastic Agents Cell Cycle Proteins medicine.disease_cause Piperazines Mice Proto-Oncogene Proteins hemic and lymphatic diseases medicine Animals Humans Protein Splicing RNA Messenger neoplasms Aged Messenger RNA Mutation biology Imidazoles Wild type Nuclear Proteins Proto-Oncogene Proteins c-mdm2 Original Articles General Medicine Middle Aged Prognosis medicine.disease Leukemia Lymphocytic Chronic B-Cell In vitro Fludarabine Real-time polymerase chain reaction Oncology Immunology Cancer research biology.protein Mdm2 Female Tumor Suppressor Protein p53 Vidarabine medicine.drug |
| Zdroj: | Cancer Sci |
| ISSN: | 1347-9032 |
| DOI: | 10.1111/cas.12008 |
| Popis: | The purpose of the present study was to investigate the prognostic significance of murine double minute 4 (MDM4) in chronic lymphocytic leukemia (CLL) and to characterize the role of MDM4 in the p53 pathway. Full‐length MDM4 (FL‐MDM4), a splicing variant of MDM4 (S‐MDM4) and murine double minute 2 (MDM2) mRNA expressions were detected by quantitative PCR in 140 Chinese patients with CLL, and primary CLL cells were treated in vitro with either fludarabine or Nutlin‐3 to explore the interaction between p53 status and MDM4 or MDM2 expression. A marked increase of FL‐MDM4 and S‐MDM4 expressions were observed in the CLL patients with p53 aberrations (deletion and/or mutation) (P = 0.024, P |
| Databáze: | OpenAIRE |
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