Dutasteride nanocapsules for hair follicle targeting: Effect of chitosan-coating and physical stimulus
| Autor: | Maíra N. Pereira, Tais Gratieri, Marcilio Cunha-Filho, Camila Y. Ushirobira, Luana A.F. Afiune, Guilherme M. Gelfuso |
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| Rok vydání: | 2019 |
| Předmět: |
Chemical Phenomena
02 engineering and technology engineering.material Biochemistry Nanocapsules Chitosan 03 medical and health sciences chemistry.chemical_compound 5-alpha Reductase Inhibitors Coating Drug Stability Structural Biology Physical Stimulation Zeta potential medicine Humans Molecular Biology 030304 developmental biology 0303 health sciences Drug Carriers General Medicine Permeation Dutasteride 021001 nanoscience & nanotechnology Hair follicle Lipids medicine.anatomical_structure chemistry Drug delivery engineering 0210 nano-technology Hair Follicle Biomedical engineering |
| Zdroj: | International journal of biological macromolecules. 151 |
| ISSN: | 1879-0003 |
| Popis: | In general, nanometer-sized drug delivery systems have a natural tendency for accommodation in the follicular cavities, which makes them advantageous in the treatment of conditions affecting these structures. Still, follicular targeting enhancement can improve therapy outcomes. Here, we compare two strategies to further promote dutasteride follicular-targeted delivery: the chemical modulation of nanosystem surface properties by coating with the natural polymer chitosan, and the application of a massage. For this, poly-(ɛ-caprolactone)-lipid-core nanocapsules (NC) containing dutasteride were developed and had their permeation profile compared to chitosan-coated nanocapsules (NC-CS). Nanocapsules showed high drug encapsulation efficiency (>94%), and stability for up to 90 days of storage. As expected, chitosan coating increased the size and zeta potential, from 199.0 ± 0.5 nm (PdI of 0.12) and − 13.6 ± 0.6 mV to 224.9 ± 3.4 nm (PdI 0.23) and + 40.2 ± 0.8 mV, respectively. Both coated and non-coated nanoparticles targeted the hair follicles compared to a drug solution. Enhanced hair follicles targeting was observed after the massage procedure, with 5 and 2-fold increases relative to NC and NC-CS, respectively. In conclusion, this work demonstrates dutasteride nanocapsules can target the follicular casts, and a simple physical stimulation can enhance 5-times the drug amount accumulated. |
| Databáze: | OpenAIRE |
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