RLIP76 Gene Variants are not Associated with Drug Response in Turkish Epilepsy Patients
| Autor: | Ugur Bilge, S Akdeniz, Ö Duman, Berrin Aktekin, Nihal Olgaç Dündar, Guven Luleci, Deniz Ozel, Senay Haspolat, Esra Manguoğlu |
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| Rok vydání: | 2011 |
| Předmět: |
Drug
rlip76 gene business.industry media_common.quotation_subject Drug resistance QH426-470 Pharmacology medicine.disease neuropharmacology polymorphism Denaturing high performance liquid chromatography Epilepsy Polymorphism (computer science) Genetics medicine epilepsy Original Article business Gene Allele frequency Genetics (clinical) Pharmacogenetics pharmacogenetics media_common |
| Zdroj: | Balkan Journal of Medical Genetics, Vol 14, Iss 1, Pp 25-30 (2011) Balkan Journal of Medical Genetics : BJMG |
| ISSN: | 1311-0160 |
| DOI: | 10.2478/v10034-011-0014-3 |
| Popis: | RLIP76Gene Variants are not Associated with Drug Response in Turkish Epilepsy PatientsApproximately 30% of epileptic patients remain untreated, in spite of trials with maximum tolerable doses of more than one drug. The RalA binding protein 1 (RALBP1/RLIP76), a multifunctional, anti-apoptotic, multidrug transporter protein, has been proposed as being responsible for the drug resistance mechanism in epilepsy. We have investigated polymorphic differences in the coding regions and exon-intron boundaries of theRLIP76gene, between 146 refractory and 155 non refractory epileptic patients in Turkey, using denaturing high performance liquid chromatography (HPLC) and sequencing analysis techniques. We have detected the following sequence variants: c.160-4G>A, c.187C>G, c.1562-38G>A, c.1670+107G>A, c.1670+93G>A, c.1670+96G>A, c.1670+100C>T, c.1670+130C>T, c.1670+131G>C, c.1670+140 G>C, and found no statistically significant correlation between allele frequencies and drug response status. We conclude that sequence variants of this gene are not involved in drug resistance in epilepsy. |
| Databáze: | OpenAIRE |
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