Mild Decarboxylative Activation of Malonic Acid Derivatives by 1,1′-Carbonyldiimidazole
| Autor: | Paul Bowles, Robert J. Rafka, Kyle R. Leeman, Danny Lafrance |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Molecular Structure
Decarboxylation fungi Organic Chemistry Imidazoles food and beverages Esters Ethylenes Ketones Malonic acid Biochemistry Medicinal chemistry Malonates chemistry.chemical_compound chemistry Nucleophile Yield (chemistry) Moiety Molecule Organic chemistry Imidazole Physical and Theoretical Chemistry Carbonyldiimidazole |
| Zdroj: | Organic Letters. 13:2322-2325 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol200575c |
| Popis: | Malonic acid derivatives undergo unusually mild decarboxylation when treated with N,N'-carbonyldiimidazole (CDI) at room temperature to generate the carbonyl imidazole moiety in high yield, which can be reacted further with a variety of nucleophiles in an efficient one-pot process. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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