Dose-dependent increases in flow-mediated dilation following acute cocoa ingestion in healthy older adults
| Autor: | Debra L. Miller, Robert P. Feehan, Allen R. Kunselman, Kevin D. Monahan, Amy G. Preston, Mary E. J. Lott |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Brachial Artery Endothelium Physiology Hemodynamics Vasodilation Placebo Catechin Beverages Eating chemistry.chemical_compound Double-Blind Method Physiology (medical) Internal medicine medicine.artery Humans Medicine Ingestion Brachial artery Flavonoids Cacao Dose-Response Relationship Drug business.industry food and beverages Middle Aged Surgery Dose–response relationship Endocrinology medicine.anatomical_structure chemistry Female Endothelium Vascular business |
| Zdroj: | Journal of Applied Physiology. 111:1568-1574 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.00865.2011 |
| Popis: | An inverse relation exists between intake of flavonoid-rich foods, such as cocoa, and cardiovascular-related mortality. Favorable effects of flavonoids on the endothelium may underlie these associations. We performed a randomized, double-blind, placebo-controlled study to test the hypothesis that acute cocoa ingestion dose dependently increases endothelium-dependent vasodilation, as measured by an increase in brachial artery flow-mediated dilation (FMD), in healthy older adults. Measurements were obtained before (preingestion) and after (1- and 2-h postingestion) ingestion of 0 (placebo), 2, 5, 13, and 26 g of cocoa in 23 adults (63 ± 2 yr old, mean ± SE). Changes in brachial artery FMD 1- and 2-h postingestion compared with preingestion were used to determine the effects of cocoa. FMD was unchanged 1 (Δ−0.3 ± 0.2%)- and 2-h (Δ0.1 ± 0.1%) after placebo (0 g cocoa). In contrast, FMD increased both 1-h postingestion (2 g cocoa Δ0.0 ± 0.2%, 5 g cocoa Δ0.8 ± 0.3%, 13 g cocoa Δ1.0 ± 0.3%, and 26 g cocoa Δ1.6 ± 0.3%: P < 0.05 compared with placebo for 5, 13, and 26 g cocoa) and 2-h postingestion (2 g cocoa Δ0.5 ± 0.3%, 5 g cocoa Δ1.0 ± 0.3%, 13 g cocoa Δ1.4 ± 0.2%, and 26 g cocoa Δ2.5 ± 0.4%: P < 0.05 compared with placebo for 5, 13, and 26 g cocoa) on the other study days. A serum marker of cocoa ingestion (total epicatechin) correlated with increased FMD 1- and 2-h postingestion ( r = 0.44–0.48; both P < 0.05). Collectively, these results indicate that acute cocoa ingestion dose dependently increases brachial artery FMD in healthy older humans. These responses may help to explain associations between flavonoid intake and cardiovascular-related mortality in humans. |
| Databáze: | OpenAIRE |
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