Exploring the anti-diabetic potential of Australian Aboriginal and Indian Ayurvedic plant extracts using cell-based assays
| Autor: | Enzo A. Palombo, Ian H. Harding, Vandana Gulati, Pankaj Gulati |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Glucose uptake
India Anti-oxidant law.invention HeLa Magnoliopsida Mice Acacia tetragonophylla law 3T3-L1 Cells Adipocytes Animals Humans Hypoglycemic Agents Medicine Euphorbia Adipogenesis biology Traditional medicine Anti-cancer Plant Extracts business.industry Australia General Medicine Lipid Metabolism biology.organism_classification Antineoplastic Agents Phytogenic Anti-diabetic Medicine Ayurvedic Curculigo orchioides Glucose Diabetes Mellitus Type 2 Complementary and alternative medicine Female Medicine Traditional business Phytotherapy Andrographis paniculata Research Article HeLa Cells |
| Zdroj: | BMC Complementary and Alternative Medicine |
| ISSN: | 1472-6882 |
| DOI: | 10.1186/s12906-015-0524-8 |
| Popis: | Background Plant-derived compounds have been used clinically to treat type 2 diabetes for many years as they also exert additional beneficial effects on various other disorders. The aim of the present study was to investigate the possible mechanism of anti-diabetic activity of twelve (seven Australian Aboriginal and five Indian Ayurvedic) plant extracts. Methods The ethanolic plant extracts were investigated for glucose uptake and adipogenesis in murine 3T3-L1 adipocytes. Cytotoxicity studies were also carried out against two cancerous cell lines, HeLa and A549, to investigate the potential anti-cancer activities of the extracts. Results Of the seven Australian Aboriginal plant extracts tested, only Acacia kempeana and Santalum spicatum stimulated glucose uptake in adipocytes. Among the five Indian Ayurvedic plant extracts, only Curculigo orchioides enhanced glucose uptake. With respect to adipogenesis, the Australian plants Acacia tetragonophylla, Beyeria leshnaultii and Euphorbia drumondii and the Indian plants Pterocarpus marsupium, Andrographis paniculata and Curculigo orchioides reduced lipid accumulation in differentiated adipocytes. Extracts of Acacia kempeana and Acacia tetragonophylla showed potent and specific activity against HeLa cells. Conclusions The findings suggest that the plant extracts exert their anti-diabetic properties by different mechanisms, including the stimulation of glucose uptake in adipocytes, inhibition of adipogenesis or both. Apart from their anti-diabetic activities, some of the extracts have potential for the development of chemotherapeutic agents for the treatment of cervical cancer. |
| Databáze: | OpenAIRE |
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