High prevalence of hepatitis C (HCV) in the emergency department (ED) of a London hospital: should we be screening for HCV in ED attendees?
| Autor: | S. Flanagan, C. Y. W. Tong, Chloe Orkin, E Wallis, E. Leach, Graham R. Foster, M. Ruf |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Epidemiology Hepatitis C virus Population Short Report medicine.disease_cause Internal medicine London Prevalence Humans Mass Screening Medicine Seroprevalence education Mass screening education.field_of_study High prevalence business.industry Transmission (medicine) virus diseases Hepatitis C Emergency department Hepatitis C Antibodies Middle Aged medicine.disease digestive system diseases Infectious Diseases Emergency medicine RNA Viral Female Emergency Service Hospital business |
| Zdroj: | Epidemiol Infect |
| ISSN: | 1469-4409 0950-2688 |
| DOI: | 10.1017/s0950268815000199 |
| Popis: | SUMMARYAn unlinked anonymous study was conducted to estimate the prevalence of hepatitis C virus (HCV) infection in emergency department (ED) attendees at a London Hospital. Nine hundred and ninety-seven samples collected over a 12-day period were tested for HCV antibody (Ab) and reactive samples were further tested for HCV RNA. The HCV seroprevalence was 2·6% (26/997) with 1·2% (12/997) HCV RNA positive. A peak HCV RNA-positive prevalence of 4·8% (3/63) was found in males aged 35–44 years, this was compared to 0% (0/136) in males aged P = 0·0614) and 1·4% (4/278) in males aged ⩾45 years (P = 0·2415). Assuming the cost for HCV Ab is £6 and HCV RNA is £40 per test, screening ED attendees aged 25–54 years would cost £360 per viraemic infection and identify 82% of those who were HCV RNA positive, yielding the most favourable cost/benefit ratio. HCV screening of ED attendees aged 25–54 years in this population could be an effective way of identifying patients and limit onward transmission. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|