Four-Stranded DNA Helices: Conformational Analysis of Regular Poly(dT) · Poly(dA) · Poly(dA) · Poly(dT) Helices with Various Types of Base Binding
| Autor: | Olga F. Borisova, Yu. P. Lysov, V. L. Florentiev, Zibrov As, I. A. Il'ychova, O. K. Mamaeva, A. A. Chernyi, Anna K. Shchyolkina |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Models
Molecular Base Composition Physics::Biological Physics Quantitative Biology::Biomolecules Mutual orientation Base Sequence Stereochemistry Molecular Sequence Data DNA General Medicine Dihedral angle Potential energy Base (group theory) Crystallography chemistry.chemical_compound Polydeoxyribonucleotides chemistry Structural Biology Yield (chemistry) Helix Nucleic Acid Conformation Conformational energy Molecular Biology |
| Zdroj: | Journal of Biomolecular Structure and Dynamics. 8:513-527 |
| ISSN: | 1538-0254 0739-1102 |
| DOI: | 10.1080/07391102.1990.10507826 |
| Popis: | The paper presents results obtained in conformational analysis of homopolymeric four- stranded poly(dT) · poly(dA) · poly(dA) · poly(dT) DNA helices in which the pairs of strands with identical bases are parallel and have a two-fold symmetry axis. All possible models of base binding to yield a symmetric complex have been considered. The dihedral angles of sugar-phosphate backbones and helix parameters, which are consistent with the minima of conformational energy for four-stranded DNAs, have been determined using the results of optimization of conformational energy calculated at atom-atom approximation. Potential energy is shown to depend on the structure of base complexes and on the mutual orientation of unlike strands. Possible biological functions of four-stranded helices are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|