Prognostic Impact of the Neutrophil-to-Lymphocyte Ratio in Stage I-II Rectal Cancer Patients
| Autor: | Kazuhito Minami, Yasushi Toh, Daisuke Yoshida, Mitsuhiko Ota, Masahiko Ikebe, Masahiko Sugiyama, Akito Matsukuma, Masaru Morita |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Multivariate analysis Neutrophils Lymphovascular invasion Colorectal cancer Systemic inflammation Gastroenterology Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine Lymphocyte Count Lymphocytes Neutrophil to lymphocyte ratio Stage (cooking) Survival rate Aged Neoplasm Staging Retrospective Studies Aged 80 and over Proctectomy Rectal Neoplasms business.industry fungi Middle Aged Prognosis medicine.disease Survival Rate 030220 oncology & carcinogenesis Preoperative Period Biomarker (medicine) Female 030211 gastroenterology & hepatology Surgery Neoplasm Recurrence Local medicine.symptom business Follow-Up Studies |
| Zdroj: | Journal of Surgical Research. 245:281-287 |
| ISSN: | 0022-4804 |
| Popis: | Background Systemic inflammation and immune response play crucial roles in tumor growth; neutrophil-to-lymphocyte ratio (NLR) is a known systemic inflammatory scoring system. Previous studies have reported that NLR is a prognostic biomarker in various human cancers. The aim of this study was to determine whether the NLR predicts tumor recurrence in patients with stage I-II rectal cancer after curative resection. Methods We retrospectively analyzed 130 consecutive patients with stage I-II rectal cancer who underwent curative resection between January 2006 and March 2015 at our institution without any preoperative treatment. We investigated whether clinicopathologic factors including NLR were associated with cancer recurrence after curative surgery. Results There were four cases (3.1%) of cancer-specific deaths and 16 cases (12.3%) of recurrence; the 5-year disease-free survival rate was 85.6%. NLR, pathologic T-category, and lymphatic invasion were significantly associated with disease-free survival. Multivariate analysis further showed that these three factors were independently associated with disease-free survival. Conclusions Preoperative NLR could predict tumor relapse in stage I-II rectal cancer and might be a useful biomarker for predicting recurrence in patients undergoing curative resection. |
| Databáze: | OpenAIRE |
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