Initial increase in glucose variability during Ramadan fasting in non-insulin-treated patients with diabetes type 2 using continuous glucose monitoring
| Autor: | Targ Elgzyri, Murtada Elbagir, Nesreen Aldawi, Salah Abusnana, Gassan Darwiche |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Waist endocrine system diseases medicine.medical_treatment Coefficient of variation Glucose variability diabetes type 2 Ramadan fasting Type 2 diabetes Islam Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Blood Glucose Self-Monitoring Diabetes mellitus Blood plasma medicine Humans 030212 general & internal medicine Ceremonial Behavior glucose variability Glycated Hemoglobin ramadan fasting business.industry Insulin nutritional and metabolic diseases Fasting General Medicine Middle Aged medicine.disease Blood pressure Diabetes Mellitus Type 2 Medicine Female Original Article business 030217 neurology & neurosurgery |
| Zdroj: | Libyan Journal of Medicine, Vol 14, Iss 1 (2019) Libyan Journal of Medicine; Vol 14, No 1 (2019); 1-5 The Libyan Journal of Medicine |
| ISSN: | 1819-6357 1993-2820 |
| Popis: | There are no studies evaluating the glucose variability in different periods of Ramadan fasting in patients with type 2 diabetes using continuous glucose monitoring (CGM). This study examined the effect of Ramadan fasting on interstitial glucose (IG) variability in early,- late-, and post-Ramadan compared to pre-Ramadan days in non-insulin-treated type 2 diabetes patients. Participants had a CGM system connected 2 or 3 days before Ramadan start, which was removed on the third or fourth day of Ramadan. CGM performance continued for a total of 6 days. A second CGM performance started on the 27th or 28th day of Ramadan and ended on the 4th or 5th post-Ramadan day. First, CGM recordings were divided into pre-Ramadan and early-Ramadan CGM, and second recordings into late-Ramadan and post-Ramadan. At each visit, blood pressure, body weight, and waist circumference were measured, and fasting blood samples were collected for HbA1c and plasma glucose. All patients received recommended Ramadan education before Ramadan. Thirty-three patients (mean age 55.0 ± 9.8 years, 73% males) were prospectively included. IG variability, estimated as mean amplitude of glycaemic excursions (MAGE), increased significantly in early-Ramadan compared to pre-Ramadan (P = 0.006) but not in late-Ramadan and post-Ramadan recording days. Only patients on >2 anti-diabetic drugs (n = 16, P = 0.019) and those on sulphonylureas (n = 14, P = 0.003) showed significant increase in MAGE in early-Ramadan. No significant changes were seen in coefficient of variation, time in range, time in hyperglycaemia, or time in hypoglycaemia. Except for an initial increase in glucose variability, fasting Ramadan for patients with non-insulin-treated type 2 diabetes did not cause any significant changes in glucose variability or time in hypoglycaemia during CGM recording days compared to nonfasting pre-Ramadan period.KEYWORDS: Glucose variability; diabetes type 2; Ramadan fasting |
| Databáze: | OpenAIRE |
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