Neuroprotective effect of Cucumis melo Var. flexuosus leaf extract on the brains of rats with streptozotocin-induced diabetes

Autor: Doaa S. Ibrahim
Rok vydání: 2016
Předmět:
Blood Glucose
Male
Vascular Endothelial Growth Factor A
0301 basic medicine
Dopamine
medicine.medical_treatment
medicine.disease_cause
Biochemistry
chemistry.chemical_compound
0302 clinical medicine
Cucumis melo
Malondialdehyde
Melatonin
biology
Caspase 3
Brain
Catalase
Neuroprotective Agents
medicine.drug
medicine.medical_specialty
Intraperitoneal injection
Diabetes Mellitus
Experimental
Superoxide dismutase
03 medical and health sciences
Cellular and Molecular Neuroscience
Diabetes mellitus
Internal medicine
medicine
Animals
Rats
Wistar
Plant Extracts
Superoxide Dismutase
Tumor Necrosis Factor-alpha
Interleukins
medicine.disease
Streptozotocin
Rats
Plant Leaves
Oxidative Stress
030104 developmental biology
Endocrinology
chemistry
biology.protein
Lipid Peroxidation
Neurology (clinical)
Glycated hemoglobin
030217 neurology & neurosurgery
Oxidative stress
Zdroj: Metabolic Brain Disease. 32:69-75
ISSN: 1573-7365
0885-7490
DOI: 10.1007/s11011-016-9886-y
Popis: The central nervous system is one of the most vulnerable organs affected by the oxidative stress associated with diabetes mellitus. Healthy food provides an important source for antioxidants. Therefore, the protective effect of Cucumis melo var. flexuosus (C. melo var. flexuosus) leaf extract on the brains of diabetic rats was investigated. Adult male albino rats divided into 5 groups of 6 rats each were assigned into a normal control group and four diabetic groups. Diabetes was induced in rats by a single intraperitoneal injection of streptozotocin (STZ; 60 mg/kg bw). One of the four diabetic groups was left untreated and was considered as a diabetic control group while the three other groups were treated with C. melo var. flexuosus leaf extract at the doses of 30, 60 and 120 mg/kg bw for a period of 30 days. After completion of experimental duration plasma and brains were used for evaluating biochemical changes. The obtained data showed that C. melo var. flexuosus leaf extract treatment lowered blood glucose, glycated hemoglobin, brain tumor necrosis factor-alpha, interleukin levels, brain malondialdehyde content and caspase-3 activity. Furthermore, the treatment resulted in a marked increase in plasma dopamine, melatonin, brain vascular endothelial growth factor-A levels, brain catalase and superoxide dismutase activities. From the present study, it can be concluded that the C. melo var. flexuosus leaf extract exerts a neuroprotective effect against oxidative damage associated with diabetes.
Databáze: OpenAIRE
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