nm23 Protein expression in larynx cancer and the relationship with metastasis
| Autor: | I.N Hosal, Metin Önerci, D Firat, B Gursel, Ayse Ayhan, Ibrahim Gullu, Ali Şefik Hoşal, M Gunduz |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Larynx Cancer Research Pathology medicine.medical_specialty Biology Metastasis Antigens Neoplasm Gene expression medicine Humans Genes Tumor Suppressor Laryngeal Neoplasms Lymph node Aged Monomeric GTP-Binding Proteins Kinase Cancer Middle Aged NM23 Nucleoside Diphosphate Kinases Prognosis medicine.disease Immunohistochemistry Metastasis Suppressor Gene medicine.anatomical_structure Oncology Lymphatic Metastasis Nucleoside-Diphosphate Kinase Carcinoma Squamous Cell Female Transcription Factors |
| Zdroj: | European Journal of Cancer. 33:2338-2341 |
| ISSN: | 0959-8049 |
| DOI: | 10.1016/s0959-8049(97)00321-3 |
| Popis: | The nm23 gene, which encodes nucleoside diphosphate (NDP) kinase, is proposed as a metastatic suppressor gene and has been demonstrated to correlate inversely with metastatic potential in several tumours. To elucidate the role of nm23 in larynx carcinomas, we examined using immunohistochemistry the expression of the nm23 protein in matched sets of primary tumours and metastatic lymph nodes. nm23 Protein was expressed in all the carcinomas as well as in non-neoplastic larynx mucosa. Overexpression of nm23 protein was found in the majority of primary tumours compared with corresponding normal mucosa, while decreased expression was associated with poor differentiation and distant metastasis and/or recurrence. No significant difference in age, sex and stage was found between primary tumours with high and low nm23 protein expression. These results suggest that decreased nm23 protein expression may play a role in metastasis and/or recurrence in larynx cancer and therefore could be used as a prognostic factor. |
| Databáze: | OpenAIRE |
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