Breast cancer risk associated with gynecologic surgery and indications for such surgery
| Autor: | Catherine Schairer, Rebecca Troisi, Ingemar Persson, Tord Naessen, Louise A. Brinton, Margareta Falkeborn |
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| Rok vydání: | 1997 |
| Předmět: |
Risk analysis
Adult Cancer Research medicine.medical_specialty medicine.medical_treatment Ovariectomy Population Endometriosis Breast Neoplasms Comorbidity Hysterectomy Cohort Studies Breast cancer Risk Factors medicine Humans Ovarian Diseases education Aged Retrospective Studies Sweden Uterine Diseases education.field_of_study Leiomyoma business.industry Oophorectomy Unilateral Oophorectomy Middle Aged medicine.disease Surgery Oncology Uterine Neoplasms Female Uterine Hemorrhage Menopause business Cohort study |
| Zdroj: | International journal of cancer. 70(2) |
| ISSN: | 0020-7136 |
| Popis: | Risk of breast cancer was assessed in relationship to gynecologic operations using data from a record-linkage study involving 15,844 women in the Uppsala Health Care Region of Sweden, who underwent surgery between 1965 and 1983. Data abstracted from medical records for the breast cancer cases and a random sample of the cohort allowed examination of risk associated with these operations in regard to menopausal status and indications for the operations. Among women who were pre-menopausal at the time of operation, a bilateral oophorectomy before the age of 50 years was associated with a 50% reduction in the risk of breast cancer compared with the background population, a reduction in risk evident within 10 years of the operation. A bilateral oophorectomy after the age of 50 years in pre-menopausal women or after a natural menopause was not associated with any reduction in risk. There were no reductions in risk associated with a unilateral oophorectomy or hysterectomy among women who were pre-menopausal at the time of operation. In fact, hysterectomy alone was associated with a slight increase in breast cancer risk when the operation was due to myomas, abnormal bleeding, and, possibly, severe forms of endometriosis but not to other reasons. Risk did not vary substantially by indications for oophorectomy, including benign ovarian neoplasms and functional ovarian cysts, though endometriosis was associated with a non-significant increase in breast cancer risk. |
| Databáze: | OpenAIRE |
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