Apoptosis, chemoresistance, and breast cancer: insights from the MCF-7 cell model system
| Autor: | Rebecca Simstein, Matthew E. Burow, Barbara S. Beckman, Amanda P. Parker, Christopher B. Weldon |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Programmed cell death Transcription Genetic Cell Survival Apoptosis Breast Neoplasms Biology Ceramides Models Biological General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Cell Line Tumor medicine Humans Autocrine signalling Protein kinase B PI3K/AKT/mTOR pathway Cell Death Tumor Necrosis Factor-alpha medicine.disease Metastatic breast cancer 030104 developmental biology MCF-7 Proto-Oncogene Proteins c-bcl-2 Drug Resistance Neoplasm 030220 oncology & carcinogenesis Signal transduction Signal Transduction |
| Zdroj: | Experimental biology and medicine (Maywood, N.J.). 228(9) |
| ISSN: | 1535-3702 |
| Popis: | The MCF-7 cell line was derived from a patient with metastatic breast cancer in 1970. Since then it has become a prominent model system for the study of estrogen receptor-positive breast cancer. With this model as a focus, this review summarizes important studies addressing tumor necrosis factor-α as a prototypical apoptosis-inducing cytokine in MCF-7 cells. Both survival and death receptor signaling pathways are discussed in terms of their role in chemotherapy-induced apoptosis as well as in chemoresistance. Novel therapeutic approaches to the treatment of breast cancer are proposed utilizing knowledge of these signaling pathways as targets. Specifically, ceramide metabolism is proposed as a novel target for chemosensitivity, perhaps combined with selective inhibitors of Bcl-2 or PI3K/Akt/nuclear factor-κB. Suggested areas of future research include translational studies manipulating candidate survival and death signaling pathways. |
| Databáze: | OpenAIRE |
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