Vasorelaxant effect of monoterpene carvacrol on isolated human umbilical artery
| Autor: | Đorđe Đukanović, Milica Gajić Bojić, Sonja Marinković, Saša Trailović, Miloš P. Stojiljković, Ranko Škrbić |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Canadian Journal of Physiology and Pharmacology |
| ISSN: | 1205-7541 0008-4212 |
| DOI: | 10.1139/cjpp-2021-0736 |
| Popis: | Carvacrol (CRV) is the main compound of essential oils extracted primarily from Thymus and Origanum species. Its various biological activities were confirmed: antioxidant, anti-inflammatory, antibacterial, antifungal, anti-tumour, antinematodal, and vasorelaxant action. Although vasodilation mediated by CRV was previously described, the exact mechanism of its action has not yet been established. Hence, the aim of this study was to investigate CRV vasoactivity on human umbilical arteries (HUA) and the different pathways involved in its mechanism of action using the tissue bath methodology. CRV caused a significant decrease in vascular tension of 5-HT-pre-contracted umbilical arteries, with EC50 of 442.13 ± 33.8 µmol/L (mean ± standard error of the mean—SEM). At 300 µmol/L, CRV shifted downward the 5-HT concentration–response curve with a statistical significance of p 2-induced contraction in Ca2+-free Krebs–Ringer bicarbonate solution and the BAY K 8644-induced contraction in Krebs–Ringer bicarbonate solution ( p 3 channel, was able to decrease the efficacy of CRV ( p 2+ channels on smooth muscle cells is the most probable mechanism of CRV-induced vasorelaxation. However, the role of TRPV3 channels in CRV-induced vasodilation of HUA cannot be excluded either. |
| Databáze: | OpenAIRE |
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