Excretion of SARS-CoV-2 in breast milk: a single-centre observational study
| Autor: | N. Yankappa, Pradeep Kumar, Lokesh Tiwari, Arun Prasad, Bhavesh Kant Chaudhary, Binod Kumar Pati, Monika Anant |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
viruses Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Breast milk neonatology Pediatrics Asymptomatic RJ1-570 Excretion 03 medical and health sciences 0302 clinical medicine Pregnancy Humans Medicine 030212 general & internal medicine Neonatology Pregnancy Complications Infectious skin and connective tissue diseases music 030219 obstetrics & reproductive medicine music.instrument Milk Human Cesarean Section SARS-CoV-2 business.industry Obstetrics fungi Infant Newborn COVID-19 Infectious Disease Transmission Vertical body regions Infectious Diseases Pediatrics Perinatology and Child Health Lower segment caesarean section RNA Viral Female Observational study medicine.symptom business Breast feeding |
| Zdroj: | BMJ Paediatrics Open, Vol 5, Iss 1 (2021) BMJ Paediatrics Open |
| ISSN: | 2399-9772 |
| DOI: | 10.1136/bmjpo-2021-001087 |
| Popis: | BackgroundBreast feeding by SARS-CoV-2-infected mothers has been a concern because of the possibility of excretion of virus in breast milk.ObjectiveTo detect SARS-CoV-2 in expressed breast milk (EBM) of mothers infected with SARS-CoV-2 and clinical outcome of neonates delivered and breast fed by them.DesignA single-centre, prospective observational study involving 50 SARS-CoV-2-infected mothers and their 51 neonates.SettingA tertiary care hospital in Eastern India.ParticipantsSARS-CoV-2-infected mothers and neonates delivered by them.Main outcome measuresWe investigated the presence of SARS-CoV-2 in the breast milk of mothers, who tested positive for this virus in their nasopharyngeal swab (NPS). Clinical outcome was assessed in neonates breast fed by these mothers after 1 month of the postnatal period.Results50 SARS-CoV-2-positive expectant mothers were enrolled for the study. One out of 51 neonates, who delivered through lower segment caesarean section at term gestation and tested SARS-CoV-2 negative, died due to severe birth asphyxia. One sample of EBM was collected from each of the 49 mothers within 4 days of delivery. All EBM samples tested negative for SARS-CoV-2 through real-time reverse transcriptase-PCR (RT-PCR). All the newborns were screened twice for presence of SARS-CoV-2 RNA in their NPS, by RT-PCR. 2 of 51 neonates had COVID-19 infection after 24 hours of life. Caregivers of 37 of 50 alive neonates responded to follow-up via telephone. Except for minor feed intolerance in one (1 of 37) neonate, all neonates were reported well after 1 month of their age.ConclusionAll the samples of breast milk were negative for SARS-CoV-2. Most of the neonates remained asymptomatic on breast feeding, whose mothers had SARS-CoV-2 infection before delivery. |
| Databáze: | OpenAIRE |
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